Usefulness of triglyceride-glucose index and homeostatic model assessment for predicting coronary microvascular dysfunction

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dc.authorscopusidTolga Sinan Güvenç / 6602421975
dc.authorwosidTolga Sinan Güvenç / JQN-5460-2023
dc.contributor.authorBulut, Mustafa
dc.contributor.authorÇelik, Fatma Betül
dc.contributor.authorGüvenç, Tolga Sinan
dc.contributor.authorYılmaz, Yusuf
dc.contributor.authorÇelik, Mehmet
dc.contributor.authorÖzyıldırım, Serhan
dc.contributor.authorGöçer, Kemal
dc.contributor.authorAşık, Murat
dc.contributor.authorKul, Şeref
dc.contributor.authorÇalışkan, Mustafa
dc.date.accessioned2025-04-18T08:48:56Z
dc.date.available2025-04-18T08:48:56Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBACKGROUND: Coronary microvascular dysfunction (CMD) is a common occurrence in individuals with insulin resistance (IR). Homeostatic model assessment for insulin resistance (HOMA-IR) is a widely used surrogate marker of IR, although recent studies suggest triglyceride-glucose (TyG) index is a superior marker of IR that had a better accuracy to predict type 2 diabetes or cardiovascular outcomes than HOMA-IR. OBJECTIVES: We aimed to assess the accuracy and usefulness of TyG index and HOMA-IR for predicting CMD as assessed with echocardiographic coronary flow reserve (CFR) measurement. METHODS: All cases included in the institutional CFR registry were retrospectively reviewed, and 656 cases without epicardial coronary artery disease and without major risk factors for atherosclerosis were included. A CFR ≤2.0 was defined as CMD. RESULTS: TyG index was available in all cases, while HOMA-IR was available in 398 cases. Both TyG index and HOMA-IR were associated with CMD on univariate analyses, while after adjustment for potential confounders HOMA-IR (odds ratio [OR]:1.38, 95% confidence interval [CI]:1.14–1.67, p = 0.001) but not TyG index (OR:1.48, 95% CI:0.82–2.67, p = 0.19) was associated with CMD. The predictive accuracy of HOMA-IR (c-statistic:0.63, 95% CI:0.54–0.72, p = 0.003) was higher than TyG index(c-statistic:0.55, 95% CI:0.47–0.63, p = 0.13), although the difference was not statistically significant (DeLong p = 0.23). There was strong evidence favoring a true difference between CMD vs. non-CMD groups for HOMA-IR (BF10:3507) but not for TyG index(BF10:0.66). CONCLUSIONS: HOMA-IR, but not TyG index, is closely associated with CMD.
dc.identifier.citationBulut, M., Celik, F. B., Guvenc, T. S., Yilmaz, Y., Celik, M., Ozyildirim, S., ... & Caliskan, M. (2024). Usefulness of triglyceride-glucose index and homeostatic model assessment for predicting coronary microvascular dysfunction. Journal of Clinical Lipidology.
dc.identifier.doi10.1016/j.jacl.2024.04.135
dc.identifier.endpagee772
dc.identifier.issn1933-2874
dc.identifier.issn1876-4789
dc.identifier.issue5
dc.identifier.pmid38955587
dc.identifier.scopus2-s2.0-85197091452
dc.identifier.scopusqualityQ1
dc.identifier.startpagee764
dc.identifier.urihttp://dx.doi.org/10.1016/j.jacl.2024.04.135
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6617
dc.identifier.volume18
dc.identifier.wosWOS:001367523900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüvenç, Tolga Sinan
dc.institutionauthoridTolga Sinan Güvenç / 0000-0002-6738-266X
dc.language.isoen
dc.publisherElsevier ltd
dc.relation.ispartofJournal of clinical lipidology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCoronary Artery Disease
dc.subjectDiabetes Mellitus
dc.subjectInsulin Resistance
dc.subjectMicrocirculation
dc.titleUsefulness of triglyceride-glucose index and homeostatic model assessment for predicting coronary microvascular dysfunction
dc.typeArticle

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