Usefulness of triglyceride-glucose index and homeostatic model assessment for predicting coronary microvascular dysfunction
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
BACKGROUND: Coronary microvascular dysfunction (CMD) is a common occurrence in individuals with insulin resistance (IR). Homeostatic model assessment for insulin resistance (HOMA-IR) is a widely used surrogate marker of IR, although recent studies suggest triglyceride-glucose (TyG) index is a superior marker of IR that had a better accuracy to predict type 2 diabetes or cardiovascular outcomes than HOMA-IR. OBJECTIVES: We aimed to assess the accuracy and usefulness of TyG index and HOMA-IR for predicting CMD as assessed with echocardiographic coronary flow reserve (CFR) measurement. METHODS: All cases included in the institutional CFR registry were retrospectively reviewed, and 656 cases without epicardial coronary artery disease and without major risk factors for atherosclerosis were included. A CFR ≤2.0 was defined as CMD. RESULTS: TyG index was available in all cases, while HOMA-IR was available in 398 cases. Both TyG index and HOMA-IR were associated with CMD on univariate analyses, while after adjustment for potential confounders HOMA-IR (odds ratio [OR]:1.38, 95% confidence interval [CI]:1.14–1.67, p = 0.001) but not TyG index (OR:1.48, 95% CI:0.82–2.67, p = 0.19) was associated with CMD. The predictive accuracy of HOMA-IR (c-statistic:0.63, 95% CI:0.54–0.72, p = 0.003) was higher than TyG index(c-statistic:0.55, 95% CI:0.47–0.63, p = 0.13), although the difference was not statistically significant (DeLong p = 0.23). There was strong evidence favoring a true difference between CMD vs. non-CMD groups for HOMA-IR (BF10:3507) but not for TyG index(BF10:0.66). CONCLUSIONS: HOMA-IR, but not TyG index, is closely associated with CMD.
Açıklama
Anahtar Kelimeler
Coronary Artery Disease, Diabetes Mellitus, Insulin Resistance, Microcirculation
Kaynak
Journal of clinical lipidology
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
18
Sayı
5
Künye
Bulut, M., Celik, F. B., Guvenc, T. S., Yilmaz, Y., Celik, M., Ozyildirim, S., ... & Caliskan, M. (2024). Usefulness of triglyceride-glucose index and homeostatic model assessment for predicting coronary microvascular dysfunction. Journal of Clinical Lipidology.
