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Öğe Analysis of Complications of a Neglected Disease: 13 Years of Experience with Liver Hydatid Cysts in a High-Volume Hospital(Multidisciplinary Digital Publishing Institute (MDPI), 2024) Azizoğlu, Mustafa; Aydoğdu, Bahattin; Kamçı, Tahsin Onat; Arslan, Serkan; Başuguy, Erol; Bilici, Salim; Okur, Mehmet HanifiBackground and Objectives: The aim of this study was to evaluate the clinical presentation, treatment outcomes, and complications associated with hepatic hydatid cysts in a pediatric population. Materials and Methods: This retrospective study analyzed 214 pediatric patients with liver hydatid cysts, focusing on clinical presentation, treatment outcomes, and associated complications. Patients were classified based on treatment modality, including non-operative management with albendazole, PAIR, and surgical intervention. This study compared cyst characteristics, recurrence rates, and complications such as cysto-biliary fistulas. Results: Among the patients, 68% (n = 145) had a single cyst and 86% (n = 184) were found to have isolated liver cysts. No significant statistical difference was observed between Group 1 and Group 2 in terms of age, gender, and basic laboratory values and general characteristics of the cysts, such as the lobe where the cyst was located, involvement of multiple organs, number of cysts, the state of cyst rupture, and recurrence; no statistically significant difference was found between the groups (p > 0.05 for each comparison). Cyst rupture incidence was 6%, and the average incidence of recurrence was 2%, with a surgical recurrence incidence of 3%. A total of 37 patients had a laparotomy, while 7 had laparoscopic surgery. In total, capitonnage was performed in 68 patients, omentopexy in 4, and cystostomy in 6. Consequently, among the treated patients (PAIR + surgery), the incidence of cysto-biliary fistula was 11%, anaphylaxis was 2%, surgical recurrence was 3%, and the incidence of reoperation (Clavien–Dindo ≥ 3) was 6%. The average follow-up period was 72 months, during which no mortality was observed. Conclusions: We identified key clinical outcomes related to both non-surgical treatments (cyst rupture and recurrence) and surgical groups (cysto-biliary fistulas, anaphylaxis, the need for reoperation, rupture, and recurrence). © 2024 by the authors.Öğe Catalytic synergy between pd nanoclusters and ligand-functionalized layered silicates for improved formic acid dehydrogenation(American chemical society, 2024) Doustkhah, Esmail; Yusufoğlu, Muhammed; El-Hosainy, Hamza; Zarenezhad, Hamaneh; Ide, Yusuke; Gutiérrez Moreno, José Julio; Assadi, M. Hussein N.The synthesis and stabilization of Pd nanoclusters on a support, as well as simultaneously achieving optimal catalytic activity, remain challenging tasks. Functionalizing the support surface with specific ligands offers a promising solution, but it often requires carefully balancing trade-offs between the reaction yield and catalyst stability. Here, we used two different ligands (propylamine and propylthiol) to functionalize the layered silicate's interlayer surface for Pd nanocluster synthesis and stabilization. For dehydrogenating formic acid, Pd nanoclusters on aminopropyl groups achieved a catalytic activity similar to 27-fold higher than that of thiopropyl groups at 70 degrees C. Our density functional calculations compared the adsorption energetics and bonding characteristics of single Pd atoms and Pd13 nanoclusters on amino- and thio-functionalized silicate surfaces. Pd-N bonds were predicted to be weaker with minimal covalency, while Pd-S bonds exhibit greater covalency due to higher 4d-3p hybridization, resulting in better stability. However, Pd-13 clusters undergo severe structural deformation on thiol-functionalized surfaces, resulting in a smaller overall surface area and diminished catalytic stability.Öğe Assessment of in vitro dynamics of pathogenic environmental Acanthamoeba T4 and T9 genotypes isolated from three recreational lakes in Klang Valley, Malaysia over the HaCaT cell monolayer(IWA Publishing, 2024) Halim, Rohaya Abdul; Halim, Hasseri; Hussain, Rosnani Hanim Mohd; Aazmi, Shafiq; Khan, Naveed Ahmed; Siddiqui, Ruqaiyyah; Anuar, Tengku ShahrulFree-living amoebae of the genus Acanthamoeba are causative agents of keratitis and amoebic encephalitis. They are widely found in various ecological environments. Therefore, the present study brings results that can help to better understand the genotypes of the environmental isolates and their pathogenicity. This study procured 26 Acanthamoeba isolates from three recreational lakes in 2022. Polymerase chain reaction amplification was performed on positive Acanthamoeba samples. The thermotolerance, osmotolerance, and cytopathogenicity in human keratinocyte (HaCaT) cells of the samples were also evaluated. The phylogenetic analysis demonstrated that 12 isolates were of genotype T4, two (T9), six (T17), four (T8), and one each from T5 and T11. The thermo- and osmotolerance assays indicated that eight Acanthamoeba samples were potentially pathogenic. Two T4 and one T9 genotype also recorded 33-, 42-, and 133-kDa serine-type proteases, respectively. The HaCaT cell monolayer revealed that three T4 and one T9 samples achieved cytopathic effects within the 50–100% range, hence significantly cytotoxic. The lactate dehydrogenase secretion results demonstrated that three (T4) and one (T9) sample exhibited exceptional toxicity (over 40%) compared to the other samples. The responses of Acanthamoeba members with similar genotypes to pathogenicity indicator assays varied considerably, rendering correlation of pathogenicity with specific genotypes challenging. © 2024 The Authors.Öğe Association Between Body Mass Index and Survival in Patients with De Novo Metastatic Non-Small Cell Lung Cancer(International Scientific Information, Inc., 2024) Ürün, Müslih; Güner, Gürkan; Sezgin, Yasin; Sakin, Abdullah; Kılıçkap, SaadettinBackground: This retrospective study from a single center included 289 patients diagnosed with advanced non-small cell lung cancer (NSCLC) between 2010 to 2017 and aimed to evaluate the effects of body mass index (BMI) on overall survival. Material/Methods: This retrospective study involved 289 patients diagnosed with metastatic-stage NSCLC at a single institution between January 2010 and December 2017. Patients were categorized into 2 groups based on their BMI at diagnosis: those with a BMI <25 kg/m2 and those with a BMI 325 kg/m2. Univariate and multivariate Cox regression analyses were conducted to identify factors associated with overall survival. Results: A total of 289 patients (241 men, 48 women) were included in the study, with a mean age of 60.1±11.1 years. Among them, 175 patients (60.6%) had a BMI less than 25 kg/m2. Multivariate analysis revealed that BMI, pathological diagnosis, and complete response after first-line treatment were independently associated with survival in patients with lung cancer. Predicted survival time was significantly shorter in the BMI <25 group than in the BMI 325 group (9.3 months vs 13.0 months, P<0.05). Conclusions: The study demonstrated that a higher BMI at the time of diagnosis is associated with improved overall survival in patients with de novo metastatic NSCLC. BMI may serve as an important prognostic factor in this patient population. Future prospective, multi-center studies are necessary to further validate the role of BMI in predicting survival outcomes in NSCLC patients across different treatment modalities. © Med Sci Monit.Öğe Associations Between Echocardiographic Right Heart Measurements With Short-Term Prognosis in Heart Failure: A Prospective Study(John Wiley and Sons Inc, 2024) Dinç Asarcıklı, Lale; İnan, Duygu; Murat, Selda; Çöllüoğlu, İnci Tuğçe; Bakhshaliyev, Nijat; Ulutaş, Zeynep; Çabuk, Gizem; Hasırcı, Senem; Naser, Abdulrahman; Ünal Dayı, Şennur; Çelik, Ahmet; Güvenç, Tolga SinanBackground: Echocardiographic right ventricular (RV) dysfunction is a strong risk determinant for prognosis in patients with heart failure (HF). Although parameters of RV systolic function are widely used to define RV dysfunction, there is scarce data to suggest these parameters are best suited to predict HF-related outcomes. Aims: We aimed to understand which morphologic or functional parameters are most closely associated with short-term mortality and HF-related hospitalization in patients with HF. Methods: A total of 191 patients from eight study centers were included to this study. A detailed echocardiographic examination was done at enrollment, and patients were followed up for 6 months via direct interviews or phone calls. Results: All right-sided echocardiographic parameters other than tricuspid annular plane systolic excursion were associated with outcomes. In a proportional hazards model that included right-heart parameters, RV longitudinal diameter (HR: 1.07, 95%CI: 1.04–1.10, p < 0.001), wall thickness (HR: 1.3, 95%CI: 1.13–1.50, p < 0.001), and tricuspid annular systolic velocity (HR: 0.90, 95%CI: 0.82–0.96, p = 0.02) were found as the independent predictors. However, only RV longitudinal dimension (HR: 1.04, 95%CI: 1.01–1.08, p = 0.01) and RV wall thickness (HR: 1.32, 95%CI: 1.10–1.60, p = 0.004) were associated with short-term outcomes after adjusting for other clinical and left-sided echocardiographic variables. On a Bayesian logistic regression model that included right-sided echocardiography variables, there was strong evidence for including either RV longitudinal diameter (BF10: 190.4) or wall thickness (BF10: 30.7) to the final model. Conclusion: Parameters of RV morphology were better predictors of short-term outcomes in HF patients. © 2024 Wiley Periodicals LLC.Öğe Biohybrid Micro/Nanorobots: Pioneering the Next Generation of Medical Technology(John Wiley and Sons Inc, 2024) Zarepour, Atefeh; Khosravi, Arezoo; Iravani, Siavash; Zarrabi, AliBiohybrid micro/nanorobots hold a great potential for advancing biomedical research. These tiny structures, designed to mimic biological organisms, offer a promising method for targeted drug delivery, tissue engineering, biosensing/imaging, and cancer therapy, among other applications. The integration of biology and robotics opens new possibilities for minimally invasive surgeries and personalized healthcare solutions. The key challenges in the development of biohybrid micro/nanorobots include ensuring biocompatibility, addressing manufacturing scalability, enhancing navigation and localization capabilities, maintaining stability in dynamic biological environments, navigating regulatory hurdles, and successfully translating these innovative technologies into clinical applications. Herein, the recent advancements, challenges, and future perspectives related to the biomedical applications of biohybrid micro/nanorobots are described. Indeed, this review sheds light on the cutting-edge developments in this field, providing researchers with an updated overview of the current potential of biohybrid micro/nanorobots in the realm of biomedical applications, and offering insights into their practical applications. Furthermore, it delves into recent advancements in the field of biohybrid micro/nanorobotics, providing a comprehensive analysis of the current state-of-the-art technologies and their future applications in the biomedical field. © 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH.Öğe Cardiac magnetic resonance speckle tracking analysis of right ventricle function in myocarditis with preserved right ventricular ejection fraction(Multidisciplinary digital publishing institute (MDPI), 2024) Özden, Özge; Ünlü, Serkan; Şahin, Ahmet Anıl; Barutçu, Ahmet; Gövdeli, Elif Ayduk; Sherif, Sara Abou; Papadopoulos, Konstantinos; Bingöl, Gülsüm; Kılıç, İsmail Doğu; Özmen, Emre; Seçkin Göbüt, Özden; Landra, Federico; Cameli, Matteo; Göktekin, ÖmerBackground and Objectives: Diagnosis of myocarditis remains a challenge in clinical practice; however, magnetic resonance imaging (CMRI) can ease the diagnostic approach by providing various parameters. The prevalence of right ventricular involvement in acute myocarditis is suggested to be more frequent than previously hypothesized. In this study, we sought to investigate subclinical RV involvement in patients with acute myocarditis and preserved RV ejection fraction (EF), using CMRI RV speckle-tracking imaging. Materials and Methods: CMRI of 27 patients with acute myocarditis (nine females, age 35.1 +/- 12.2 y) was retrospectively analyzed. A control group consisting of CMRI images of 27 healthy individuals was included. Results: No significant differences were found regarding left ventricle (LV) and atrium dimensions. LV ejection fraction was significantly different between groups (56.6 +/- 10.6 vs. 62.1 +/- 2.6, p < 0.05). No significant differences were present between parameters used for conventional assessment of RV. However, RV strain absolute values were significantly lower in the acute myocarditis group in comparison with that of the control group (18.4 +/- 5.4 vs. 21.8 +/- 2.8, p = 0.018). Conclusions: Subclinical RV dysfunction detected by CMR-derived strain may be present in patients with acute myocarditis even with preserved RVEF.Öğe The effects of microsurgical varicocelectomy performed for infertility on premature ejaculation(Springer science and business media b.v., 2024) Kızılkan, Yalçın; Duran, Mesut Berkan; Kayra, Mehmet Vehbi; Şahin, Bahadır; Yavuz, AbdulmecitPurpose To investigate the effects of varicocelectomy on premature ejaculation (PE) in patients with varicocele and infertility. Methods A total of 82 sexually active patients aged 18 years or over who had undergone microscopic subinguinal varicocelectomy with a clinical diagnosis of varicocele in 14 urology clinics between October 2021 and March 2023 with primary infertility were evaluated prospectively Patients were evaluated using the Turkish validated form of the 'Premature Ejaculation Diagnostic Tool' (PEDT) scale. A PEDT score of 11 or above was taken to indicate the presence of PE. Turkish validated forms of PEDT and International Index of Erectile Function-5 (IIEF-5) were completed in all patients pre-operatively and at 3 and 6 months post-operatively. Intravaginal ejaculatory latency time (IELT) and serum testosterone measurements were also recorded. Results Left varicocelectomy was performed in 70.7% and bilateral varicocelectomy in 29.3% of the participants. A significant difference was found between pre- and post-operative PEDT scores (x 2 (2) = 130.1, p < 0.001). A significant difference was observed between pre- and post-operative IELT time (x 2 (2) = 143.2, p < 0.001). IIEF-5 scores differed before and after surgery (x 2 (2) = 59.5, p < 0.001). A difference was found between the testosterone levels measured before and after surgery (x 2 (2) = 40.9, p < 0.001). No statistically significant difference was observed between the third- and sixth-month testosterone values (p = 0.183). Testosterone levels (p = 0.001) and IELT scores (p < 0.001) were significantly higher, while PEDT scores (p < 0.001) were significantly lower in the bilateral varicocelectomy group at the sixth post-operative month. Conclusion In light of our findings, it is recommended that infertile patients with varicocele be informed of the positive effects of varicocelectomy on PE.Öğe The effect of ultrasound-guided erector spinae plane block on postoperative opioid consumption and respiratory recovery in laparoscopic sleeve gastrectomy: a randomized controlled study(Springer, 2024) Karaveli, Arzu; Kaplan, Serdar; Kavaklı, Ali Sait; Koşar, Mehmet Nuri; Mayir, BurhanBackground The aim of this prospective, randomized, controlled study was to evaluate the effect of ultrasound (US)-guided bilateral erector spinae plane (ESP) block on postoperative opioid consumption and respiratory recovery in patients with obesity undergoing laparoscopic sleeve gastrectomy (LSG). Methods The study was conducted on 40 patients scheduled for LSG. The patients were randomly allocated into either the ESP block group or the control group. The US-guided bilateral ESP block was performed preoperatively. The control group received no intervention. Results Postoperative median [IQR] tramadol consumption was significantly lower in the ESP block group [150.0 [100-200] mg vs 450.0 [400-500] mg, p < 0.0001]. Postoperative spirometric variables were significantly impaired in both groups, compared with preoperative variables (p < 0.0001). Intraoperative median [IQR] fentanyl consumption was 200.0 [200-200] mu g in the ESP block group, and 350.0 [300-400] mu g in the control group (p < 0.0001). Postoperative mean pain scores at rest and during movement were significantly lower in the ESP block group, at all time points (p < 0.05). In terms of mean arterial PH, Horowitz ratio, and PaCO2, there was no statistically significant difference between the groups (p > 0.05). None of the patients experienced postoperative respiratory adverse events and/or block-related complications. Conclusions US-guided bilateral ESP block significantly reduced both intraoperative and postoperative analgesic consumptions and provided effective postoperative pain control for patients with obesity undergoing bariatric surgery. Following bariatric surgery, all patients' postoperative pulmonary functions deteriorated. The effect of US-guided bilateral ESP block on postoperative respiratory recovery could not be clearly demonstrated. Randomized controlled studies with a larger patient population are necessary.Öğe The connection between anemia and limitations in daily activities among older males: the critical role of dynapenia(Springer science and business media deutschland GmbH, 2024) Karışmaz, Abdulkadir; Soysal, Pınar; Eren, Rafet; Serin, İstemi; Aslan, Ceyda; Rahmati, Masoud; Yon, Dong Keon; Smith, LeeAim The aim of the present study was to examine the relationship between anemia and basic and instrumental activities of daily living in older male patients. Methods A total of 223 older males attending one geriatric outpatient clinic were included in this cross-sectional study. Anemia was defined as a hemoglobin level below 13 g/dL. Patients' demographic characteristics, comorbidities, and comprehensive geriatric assessment parameters were also recorded. Handgrip strength of < 27 kg for males was accepted as dynapenia. Basic Activities of Daily Living (BADL) and Instrumental Activities of Daily Living (IADL) questionnaires were used to evaluate functional capacity. Results The mean age (standard deviation) of the participants was 80.17 (7.69) years. The prevalence of patients with anemia was 43.9%. There was differences between anemic and non-anemic groups in terms of presence of diabetes mellitus (DM), congestive heart failure (CHF), chronic kidney disease (CKD), malnutrition, dynapenia, geriatric depression, BADL and IADL scores (all p < 0.05). In multivariate analysis, after adjusting for all confounding variables except for dynapenia, patients with anemia were associated with reduced BADL and IADL (all p < 0.05). After adjusting for all confounding variables including dynapenia, deterioration in total BADL and IADL scores did not remain significant in the anemic group compared to the non-anemic group (p > 0.05). Conclusion Close to one in two older outpatient men had anemia. Anemic men had a higher incidence of DM, CHF, CKD, malnutrition, geriatric depression and dynapenia. Anemia was associated with dependence in both BADL and IADL in older men. However, comorbidities, nutritional status, depressive mood and, specifically muscle strength, were important contributors to this association.Öğe The combustion of lemon peel oil/gasoline blends in spark ignition engine with high-insulation piston crown coating(Nature research, 2024) Saravanan C.G.; Varuvel, Edwin Geo; Vikneswaran M.; Bai, Femilda Josephin Joseph Shobana; Chinnathambi, Arunachalam; Pugazhendhi, Arivalagan; Allasi, Haiter LeninThis study explored the recovery of oil from lemon peel biomass and then tested it in a spark ignition as a substitute for gasoline. The study adopted the micro-arc oxidation coating technique, intending to improve the engine performance of the lemon peel oil-gasoline blends. The oil was recovered from discarded lemon peel biomass using steam distillation and then tested in the engine as a fuel by blending it with gasoline at volume ratios of 10, 20, and 30%. An endoscopic visualization approach was employed in this research work to assess the combustion initiation and flame characteristics of gasoline and lemon peel oil blends under different test conditions. Compared to gasoline and blends comprising 20 and 30% lemon peel oil, the 10% lemon peel oil mix produced higher thermal efficiency and lower emissions. The optical analysis demonstrated that premixed combustion with the 10% blend was found to be the highest, resulting in improved combustion and subsequently increased cylinder pressure. To improve the engine performance of the lemon peel oil blends with higher substitution (20 and 30%), the piston was coated with a ceramic coating. A novel technique, namely the micro-arc oxidation technique, was utilized for the coating. The coated piston engine fueled with a 20% lemon peel oil blend showed a 3% and 4.69% increase in thermal efficiency compared to the uncoated piston fueled with a 20% blend and sole gasoline, respectively. The hydrocarbon and carbon monoxide emissions of the engine with a coated piston fueled by the 20% lemon peel oil blend were reduced by 12.7% and 12%, respectively, as compared to gasoline operation in the engine with an uncoated piston.Öğe Effects of internal iliac artery ligation on stress and urge incontinence: a retrospective evaluation(Springer, 2024) Akay, Emrullah; Gül, Alime Dilayda Uzun; Mutlu, Enes Burak; Nalbant, Ayşe Ceren; Irmak, Kübra; Ersan, FıratIntroduction: Does bilateral internal iliac artery ligation (BIIAL), a fundamental intervention in the treatment of postpartum hemorrhage, increase the risk of urinary incontinence (UI)? This study aims to shed light on the effects of BIIAL on bladder perfusion and urinary system integrity, thereby elucidating urinary function disorders following pelvic surgery. Methods: Demographic and medical data were collected from a total of 192 female patients, with and without the application of BIIAL. Urinary incontinence conditions were assessed using the Questionnaire for Urinary Incontinence Diagnosis (QUID) test. The data collection process was conducted according to ethical standards, and the results were analyzed to determine the types of incontinence. Results: In the group that underwent BIIAL, the number of pregnancies and births was statistically higher compared to the control group. A significant effect of BIIAL was seen in cases of urge urinary incontinence (UUI), while no meaningful impact was detected on stress urinary incontinence (SUI). After the BIIAL procedure, an increase in the rate of urinary leakage was seen in certain cases. Conclusion: Bilateral internal iliac artery ligation has proven to be a safe and effective intervention in the management of postpartum hemorrhage. The findings suggest a potential impact of BIIAL on UUI but not on SUI. Comprehensive and long-term prospective studies are needed to further investigate the effects of BIIAL on pelvic blood flow and bladder functions.Öğe Managing recurrent parvovirus B19-associated anemia after a pediatric kidney transplant(Springer, 2024) Sabancı, Mehmet; Taşdemir, Mehmet; Öksüz, Burcu; Torun, Yasemin Altuner; Sütçü, Murat; Özkaya, OzanA 13-year-old girl who had a kidney transplant four weeks prior presented with a 10-day history of fatigue, paleness, and headache. On physical examination, tachycardia and paleness were noted. Laboratory testing was notable for severe anemia and mild leukopenia and thrombocytopenia. Polymerase chain reaction (PCR) test for Epstein-Barr virus (EBV) and cytomegalovirus (CMV) were negative and for parvovirus B19 (PVB19) was positive. Despite lower immunosuppression and administration of intravenous immunoglobulin (IVIG) it persisted for 15 months, and frequent red blood cell transfusions were needed. PVB19 is a less common but significant complication. The patient's clinical course demonstrates the importance of this complication and the challenges in its management. A notable void exists in the literature regarding standardized treatment protocols for PVB19-induced recurrent anemia after kidney transplant. This case indicates the need for further research and consensus to guide effective clinical interventions in similar cases.Öğe Machine learning approach for predicting the impact of food insecurity on nutrient consumption and malnutrition in children aged 6 months to 5 years(MDPI, 2024) Qasrawi, Radwan; Sgahir, Sabri; Nemer, Maysaa; Halaikah, Mousa; Badrasawi, Manal; Amro, Malak; Polo, Stephanny Vicuna; Abu Al-Halawa, Diala; Mujahed, Doa'a; Nasreddine, Lara; Elmadfa, Ibrahim; Atari, Siham; Al-Jawaldeh, AyoubBackground: Food insecurity significantly impacts children's health, affecting their development across cognitive, physical, and socio-emotional dimensions. This study explores the impact of food insecurity among children aged 6 months to 5 years, focusing on nutrient intake and its relationship with various forms of malnutrition. Methods: Utilizing machine learning algorithms, this study analyzed data from 819 children in the West Bank to investigate sociodemographic and health factors associated with food insecurity and its effects on nutritional status. The average age of the children was 33 months, with 52% boys and 48% girls. Results: The analysis revealed that 18.1% of children faced food insecurity, with household education, family income, locality, district, and age emerging as significant determinants. Children from food-insecure environments exhibited lower average weight, height, and mid-upper arm circumference compared to their food-secure counterparts, indicating a direct correlation between food insecurity and reduced nutritional and growth metrics. Moreover, the machine learning models observed vitamin B1 as a key indicator of all forms of malnutrition, alongside vitamin K1, vitamin A, and zinc. Specific nutrients like choline in the "underweight" category and carbohydrates in the "wasting" category were identified as unique nutritional priorities. Conclusion: This study provides insights into the differential risks for growth issues among children, offering valuable information for targeted interventions and policymaking.Öğe Power regulation of variable speed multi rotor wind systems using fuzzy cascaded control(Nature research, 2024) Benbouhenni, Habib; Çolak, İlhami; Bizon, Nicu; Mosaad, Mohamed I.; Tella, Teshome GoaPower quality is a crucial determinant for integrating wind energy into the electrical grid. This integration necessitates compliance with certain standards and levels. This study presents cascadedfuzzy power control (CFPC) for a variable-speed multi-rotor wind turbine (MRWT) system. Fuzzy logic is a type of smart control system already recognized for its robustness, making it highly suited and reliable for generating electrical energy from the wind. Therefore, the CFPC technique is proposed in this work to control the doubly-fed induction generator (DFIG)-based MRWT system. This proposed strategy is applied to the rotor side converter of a DFIG to improve the current/power quality. The proposed control has the advantage of being model-independent, as it relies on empirical knowledge rather than the specific characteristics of the DFIG or turbine. Moreover, the proposed control system is characterized by its simplicity, high performance, robustness, and ease of application. The implementation of CFPC management for 1.5 MW DFIG-MRWT was carried out in MATLAB environment considering a variable wind speed. The obtained results were compared with the direct power control (DPC) technique based on proportional-integral (PI) controllers (DPC-PI), highlighting that the CFPC technique reduced total harmonic distortion by high ratios in the three tests performed (25%, 30.18%, and 47.22%). The proposed CFPC technique reduced the response time of reactive power in all tests by ratios estimated at 83.76%, 65.02%, and 91.42% compared to the DPC-PI strategy. Also, the active power ripples were reduced by satisfactory proportions (37.50%, 32.20%, and 38.46%) compared to the DPC-PI strategy. The steady-state error value of reactive power in the tests was low when using the CFPC technique by 86.60%, 57.33%, and 72.26%, which indicates the effectiveness and efficiency of the proposed CFPC technique in improving the characteristics of the system. Thus this control can be relied upon in the future.Öğe Mechanical properties of high- and low-fusing zirconia veneering ceramics fired on different trays and substrates(MDPI, 2024) Hoffmann, Moritz; Coldea, Andrea; Dönmez, Mustafa Borga; Meinen, JohnThis study aimed to evaluate the effect of ceramic type, firing tray, and firing substrate on the density, shrinkage, biaxial flexural strength, Martens' hardness, and elastic indentation modulus of zirconia veneering ceramics. Disk-shaped specimens were fabricated from a high-fusing (HFZ) and a low-fusing (STR) zirconia veneering ceramic. These specimens were then divided into 10 groups according to firing trays (round, small honeycomb-shaped, cordierite [RSC]; round, large honeycomb-shaped, aluminum oxide [RLA]; rectangular, plane, silicon nitride [RCPS]; round, plane, silicon nitride [RPS]; and rectangular, plane, calcium silicate [RCPC]) and firing substrates (firing cotton and platinum foil) used (n = 12). The density, shrinkage, biaxial flexural strength, Martens' hardness, and indentation modulus were measured, and analyzed with generalized linear model analysis (alpha = 0.05). The interaction between the ceramic type and firing substrate affected density (p < 0.001), and the other outcomes were affected by the interaction among all main factors (p <= 0.045). Higher density was observed with HFZ or platinum foil (p <= 0.007). RSC and RLA led to a higher density than RCPS within HFZ and led to the lowest density within STR (p <= 0.046). STR had a higher shrinkage (p < 0.001). RSC mostly led to a lower shrinkage of HFZ (p <= 0.045). The effect of ceramic type and firing substrates on the biaxial flexural strength, Martens' hardness, and indentation modulus was minimal while there was no clear trend on the effect of firing tray on these properties. Ceramic type, firing tray, and firing substrate affected the mechanical properties of the tested zirconia veneering ceramics. Firing the tested zirconia veneering ceramics over a round and small honeycomb-shaped cordierite firing tray with firing cotton mostly led to improved mechanical properties.Öğe Daratumumab maintenance in patients with myeloma(Elsevier, 2024) Beksac, MeralDaratumumab maintenance in patients with myelomaÖğe Evaluation of the effect of morphological structure on dilatational tracheostomy interference location and complications with ultrasonography and fiberoptic bronchoscopy(MDPI, 2024) Bulut, Esin; Yıldız, Ülkü Arslan; Cengiz, Melike; Yılmaz, Murat; Kavaklı, Ali Sait; Arıcı, Ayşe Gülbin; Öztürk, NihalBackground: Percutaneous dilatational tracheostomy (PDT) is the most commonly performed minimally invasive intensive care unit procedure worldwide. Methods: This study evaluated the percentage of consistency between the entry site observed with fiberoptic bronchoscopy (FOB) and the prediction for the PDT level based on pre-procedural ultrasonography (USG) in PDT procedures performed using the forceps dilatation method. The effect of morphological features on intervention sites was also investigated. Complications that occurred during and after the procedure, as well as the duration, site, and quantity of the procedures, were recorded. Results: Data obtained from a total of 91 patients were analyzed. In 57 patients (62.6%), the USG-estimated tracheal puncture level was consistent with the intercartilaginous space observed by FOB, while in 34 patients (37.4%), there was a discrepancy between these two methods. According to Bland Altman, the agreement between the tracheal spaces determined by USG and FOB was close. Regression formulas for PDT procedures defining the intercartilaginous puncture level based on morphologic measurements of the patients were created. The most common complication related to PDT was cartilage fracture (17.6%), which was proven to be predicted with maximum relevance by punctured tracheal level, neck extension limitation, and procedure duration. Conclusions: In PDT procedures using the forceps dilatation method, the prediction of the PDT intervention level based on pre-procedural USG was considerably in accordance with the entry site observed by FOB. The intercartilaginous puncture level could be estimated based on morphological measurements.Öğe Letter to the editor: considering poststroke fatigue(Lippincott williams & wilkins, 2024) Küçükakgün, Hilalnur; Tulek, Zeliha; Kılıçaslan, Kimya; Uncu, Jbid Dursun; Bayrak, Ceren; Soltanalizadeh, Roya; Krespi, YakupLetter to the editor: considering poststroke fatigueÖğe Machine learning and experimental analyses identified miRNA expression models associated with metastatic osteosarcoma(Elsevier, 2024) Abedi, Samira; Behmanesh, Ali; Mazhar, Farid Najd; Bagherifard, Abolfazl; Sami, Sam Hajialiloo; Heidari, Negar; Hossein-Khannazer, Nikoo; Namazifard, Saina; Arki, Mandana Kazem; Shams, Roshanak; Zarrabi, Ali; Vosough, MassoudOsteosarcoma (OS), as the most common primary bone cancer, has a high invasiveness and metastatic potential, therefore, it has a poor prognosis. This study identified early diagnostic biomarkers using miRNA expression profiles associated with osteosarcoma metastasis. In the first step, we used RNA-seq and online microarray data from osteosarcoma tissues and cell lines to identify differentially expressed miRNAs. Then, using seven feature selection algorithms for ranking, the first-ranked miRNAs were selected as input for five machine learning systems. Using network analysis and machine learning algorithms, we developed new diagnostic models that successfully differentiated metastatic osteosarcoma from non-metastatic samples based on newly discovered miRNA signatures. The results showed that miR-34c-3p and miR-154-3p act as the most promising models in the diagnosis of metastatic osteosarcoma. Validation for this model by RT-qPCR in benign tissue and osteosarcoma biopsies confirmed the lower expression of miR-34c-3p and miR-154-3p in OS samples. In addition, a direct correlation between miR-34c-3p expression, miR-154-3p expression and tumor grade was discovered. The combined values of miR-34c-3p and miR-154-3p showed 90 % diagnostic power (AUC = 0.90) for osteosarcoma samples and 85 % (AUC = 0.85) for metastatic osteosarcoma. Adhesion junction and focal adhesion pathways, as well as epithelial-to-mesenchymal transition (EMT) GO terms, were identified as the most significant KEGG and GO terms for the top miRNAs. The findings of this study highlight the potential use of novel miRNA expression signatures for early detection of metastatic osteosarcoma. These findings may help in determining therapeutic approaches with a quantitative and faster method of metastasis detection and also be used in the development of targeted molecular therapy for this aggressive cancer. Further research is needed to confirm the clinical utility of miR-34c-3p and miR-154-3p as diagnostic biomarkers for metastatic osteosarcoma.
