The shape of the corpus callosum is different in bipolar disorder
Yükleniyor...
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cambridge University press
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Bipolar disorder (BD) is a recurrent chronic disorder characterised by fluctuations in mood and energy disposition. Diseases could lead to degenerative alterations in brain structures such as corpus callosum (CC). Studies demonstrated that abnormalities in CC are associated with BD symptoms. The present study aims to analyse the CC of the patients with statistical shape analysis (SSA) and compare the findings with healthy controls. Methods: Forty-one BD patients and 41 healthy individuals in similar age groups, which included 23 female and 18 male subjects, participated in the study. CC was marked with landmarks on the mid-sagittal images of each individual. The mean ' Procrustes ' point was calculated, and shape deformations were analysed with thin-plate spline analysis. Results: Significant differences were observed in the shape of CC between the two groups, where maximum CC deformation was observed in posterior region marks in BD patients. There was no significant difference between the CC area of the BD patients and controls. Conclusions: CC analysis conducted with SSA revealed significant differences between patients and healthy controls. The study findings emphasised the abnormal distribution of white matter in CC and the variable subregional nature of CC in BD patients. This study may enable the development of more targeted and effective treatment strategies by taking into account biological factors and understanding the differences in the brain regions of individuals with BD.
Açıklama
Anahtar Kelimeler
Corpus Callosum, Bipolar Disorder, Magnetic Resonance Imaging, Neuroimaging, Computer-Assisted Image Processing
Kaynak
Acta neuropsychiatrica
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
37
Sayı
Künye
Namli, M. N., Baykara, S., Gul, O., & Baykara, M. (2025). The shape of the corpus callosum is different in bipolar disorder. Acta Neuropsychiatrica, 37, e36.
