Gut matters in microgravity: potential link of gut microbiota and its metabolites to cardiovascular and musculoskeletal well-being

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dc.authorscopusidAhmed Navee Khan/58685542900
dc.authorscopusidRuqaiyyah Siddiqui/18635417000
dc.authorwosidAhmed Navee Khan/FXL-5617-2022
dc.authorwosidRuqaiyyah Siddiqui/ FVT-1496-2022
dc.contributor.authorİbrahim, Zeinab
dc.contributor.authorKhan, Navee Ahmed
dc.contributor.authorSiddiqui, Ruqaiyyah
dc.contributor.authorQaisar, Rizwan
dc.contributor.authorMarzook, Hezlin
dc.contributor.authorSoares, Nelson C.
dc.contributor.authorElmoselhi, Adel B
dc.date.accessioned2025-04-18T10:12:15Z
dc.date.available2025-04-18T10:12:15Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractThe gut microbiota and its secreted metabolites play a significant role in cardiovascular and musculoskeletal health and diseases. The dysregulation of the intestinal microbiota poses a significant threat to cardiovascular and skeletal muscle well-being. Nonetheless, the precise molecular mechanisms underlying these changes remain unclear. Furthermore, microgravity presents several challenges to cardiovascular and musculoskeletal health compromising muscle strength, endothelial dysfunction, and metabolic changes. The purpose of this review is to critically examine the role of gut microbiota metabolites on cardiovascular and skeletal muscle functions and dysfunctions. It also explores the molecular mechanisms that drive microgravity-induced deconditioning in both cardiovascular and skeletal muscle. Key findings in this review highlight that several alterations in gut microbiota and secreted metabolites in microgravity mirror characteristics seen in cardiovascular and skeletal muscle diseases. Those alterations include increased levels of Firmicutes/Bacteroidetes (F/B) ratio, elevated lipopolysaccharide levels (LPS), increased in para-cresol (p-cresol) and secondary metabolites, along with reduction in bile acids and Akkermansia muciniphila bacteria. Highlighting the potential, modulating gut microbiota in microgravity conditions could play a significant role in mitigating cardiovascular and skeletal muscle diseases not only during space flight but also in prolonged bed rest scenarios here on Earth. © The Author(s) 2024.
dc.identifier.citationIbrahim, Z., Khan, N. A., Siddiqui, R., Qaisar, R., Marzook, H., Soares, N. C., & Elmoselhi, A. B. (2024). Gut matters in microgravity: potential link of gut microbiota and its metabolites to cardiovascular and musculoskeletal well-being. Nutrition & Metabolism, 21(1), 66.
dc.identifier.doi10.1186/s12986-024-00836-6
dc.identifier.issn17437075
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85200900256
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1186/s12986-024-00836-6
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6989
dc.identifier.volume21
dc.identifier.wosWOS:001287653400002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorKhan, Ahmed Navee
dc.institutionauthorSiddiqui, Ruqaiyyah
dc.institutionauthorSiddiqui
dc.institutionauthoridAhmed Navee Khan/0000-0001-7667-8553
dc.institutionauthoridRuqaiyyah Siddiqui/0000-0001-9646-6208
dc.language.isoen
dc.publisherBioMed Central Ltd
dc.relation.ispartofNutrition and Metabolism
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCardiovascular
dc.subjectDeconditioning
dc.subjectGut
dc.subjectMetabolites
dc.subjectMicrobiota
dc.subjectMicrogravity
dc.subjectSkeletal Muscle
dc.titleGut matters in microgravity: potential link of gut microbiota and its metabolites to cardiovascular and musculoskeletal well-being
dc.typeOther

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