Understanding of clinical trials among patients with cancer and their relatives

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dc.authorscopusidİrfan Çiçin / 8922379100
dc.authorscopusidSaadettin Kılıçkap / 8665552100
dc.authorwosidİrfan Çiçin / JQU-1347-2023
dc.authorwosidSaadettin Kılıçkap / AAP-3732-2021
dc.contributor.authorTolunay, Pinar Kubilay
dc.contributor.authorErol, Cihan
dc.contributor.authorKahraman, Seda
dc.contributor.authorTacar, Seher Yıldız
dc.contributor.authorÖzcan, Erkan
dc.contributor.authorBasal, Fatma Buğdaycı
dc.contributor.authorKöse, Fatih
dc.contributor.authorSendur, Mehmet Ali Nahit
dc.contributor.authorTural, Deniz
dc.contributor.authorÇiçin, İrfan
dc.contributor.authorÖksüzoğlu, Berna
dc.contributor.authorKılıçkap, Saadettin
dc.date.accessioned2025-04-18T06:52:22Z
dc.date.available2025-04-18T06:52:22Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractImportanceClinical trials are vital for advancing cancer treatments and improving patient outcomes. Understanding the factors that influence participants' decision-making is critical for enhancing trial recruitment. ObjectiveTo evaluate the attitudes of patients with cancer and their relatives toward clinical trial participation, identifying key barriers and motivators that affect their willingness to engage in such trials. Design, Setting, and ParticipantsThis cross-sectional survey study was conducted between April 2020 and April 2021. Face-to-face questionnaires were administered by physicians across 6 tertiary hospital medical oncology departments in Turkey. Adults with cancer and their relatives were recruited. Data were analyzed from April to December 2021. ExposureParticipants' knowledge, perceptions, and motivations regarding clinical trial participation were assessed through a structured questionnaire. Main Outcomes and MeasuresParticipants' demographic information, their willingness to participate in clinical trials, their perceptions about the clinical trial participation, and the facilitators and barriers to participation. ResultsA total of 978 participants were surveyed, with a median (range) age of 52 (18-82) years; 485 (49.6%) were male and 479 (49.0%) female. Of these, 578 (59.1%) were patients with cancer and 382 (39.1%) family members. Prior clinical trial experience was reported by 174 participants (17.8%), and 428 (43.8%) expressed a willingness to participate in clinical trials. Participants well-informed about clinical trials showed higher willingness (50 of 87 [57.5%] very willing) compared with those with no knowledge (27 of 303 [8.9%] very willing) (chi(2 )= 275.095; P < .001). Greater willingness was observed in participants from less developed cities compared with the most developed cities (88 of 321 [27.4%] vs 94 of 615 [15.3%]; chi(2 )= 21.093; P < .001), in individuals with a high school degree or greater compared with those with less than a high school degree (105 of 489 [21.5%] vs 76 of 452 [16.8%]; chi(2) = 33.311; P < .001), in those with monthly incomes above compared with below the poverty line (81 of 409 [19.8%] vs 100 of 512 [19.5%]; chi(2 ) = 16.145; P = .003), in those without prior cancer treatment compared with those with prior cancer treatment (125 of 591 [21.2%] vs 40 of 289 [13.8%]; chi(2 ) = 13.801; P = .008), and in participants with prior trial experience compared with those without (74 of 166 [44.6%] vs 111 of 786 [14.1%]; chi(2 )= 87.771; P < .001). Participants were motivated by potential personal health benefits (604 [61.8%]) and access to new treatments (522 [53.4%]). The primary concerns included potential adverse effects (555 [56.7%]), feeling like a "test subject" (284 [29.0%]), and the risk of receiving a placebo (197 [20.1%]). Conclusions and RelevanceIn this survey study of patients with cancer and their relatives, significant gaps in knowledge and persistent concerns about clinical trial safety were highlighted, impacting participation. Addressing these concerns through targeted education and transparent communication is essential for improving participation rates and ensuring more inclusive cancer research.
dc.identifier.citationTolunay, P. K., Erol, C., Kahraman, S., Tacar, S. Y., Özcan, E., Başal, F. B., ... & Ürün, Y. (2025). Understanding of Clinical Trials Among Patients With Cancer and Their Relatives. JAMA Network Open, 8(1), e2457020-e2457020.
dc.identifier.doi10.1001/jamanetworkopen.2024.57020
dc.identifier.endpage14
dc.identifier.issn2574-3805
dc.identifier.issue1
dc.identifier.pmid39874033
dc.identifier.scopus2-s2.0-85217189899
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1001/jamanetworkopen.2024.57020
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6385
dc.identifier.volume8
dc.identifier.wosWOS:001411679900007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇiçin, İrfan
dc.institutionauthorKılıçkap, Saadettin
dc.institutionauthoridİrfan Çiçin / 0000-0002-7584-3868
dc.institutionauthoridSaadettin Kılıçkap / 0000-0003-1637-7390
dc.language.isoen
dc.publisherAmer medical assoc
dc.relation.ispartofJAMA network open
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleUnderstanding of clinical trials among patients with cancer and their relatives
dc.typeArticle

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