The comparison of contribution of GO and rGO produced by green synthesis to the properties of CMC-based wound dressing material

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dc.authorscopusidAyça Bal Öztürk / 57062000100
dc.authorscopusidBurçin İzbudak / 57221779519
dc.authorwosidAyça Bal Öztürk / KRG-6786-2024
dc.authorwosidBurçin İzbudak / GXP-7807-2022
dc.contributor.authorKaraca, Özge Gülüzar
dc.contributor.authorMoran, Büşra
dc.contributor.authorTürk, Mustafa
dc.contributor.authorBal-Öztürk, Ayça
dc.contributor.authorİzbudak, Burçin
dc.contributor.authorAydın, Yaşar Andelib
dc.contributor.authorUtkan, Güldem
dc.contributor.authorAlemdar, Neslihan
dc.date.accessioned2025-04-18T09:45:37Z
dc.date.available2025-04-18T09:45:37Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümü
dc.description.abstractHerein, GO (graphene oxide) or rGO (reduced graphene oxide) which is produced by the green synthesis method using plant extract (Laurus nobilis) was incorporated into a polymeric structure consisting of carboxymethyl cellulose (CMC) and polyethylene glycol (PEG) to produce a wound dressing material with enhanced mechanical and electrical properties. The effect of GO and rGO on the wound dressing features of the produced materials was investigated and compared to each other. Conductivity tests demonstrated that rGO contributed more significantly to the electrical conductivity than GO. While rGO-CMC/PEG/CA reached 3.01 x 10-6 S.cm- 1 as the conductivity value, that of GO-CMC/PEG/CA was determined as 0.85 x 10-6 S.cm- 1. As for the mechanical tests, it was seen that rGO achieved the best results in terms of elastic modulus (588.62 N/mm2), tensile strength (94.95 MPa) and elongation at break (17.64 %) compared to GO reinforced and pure hydrogel. Curcumin and ascorbic acid were used for antibiotic-free wound treatment and their release kinetics were also modeled. The results showed that rGO reinforced hydrogel provided a more controlled release. All results assured that both the produced GO reinforced and especially rGO reinforced hydrogels could be utilized as modern wound dressing materials with suitable properties to achieve remarkable results for wound healing.
dc.description.sponsorshipScientific Research Projects Commission (BAPKO) of Marmara University
dc.identifier.citationKaraca, Ö. G., Moran, B., Türk, M., Bal-Öztürk, A., İzbudak, B., Aydin, Y. A., ... & Alemdar, N. (2024). The comparison of contribution of GO and rGO produced by green synthesis to the properties of CMC-based wound dressing material. International Journal of Biological Macromolecules, 271, 132521.
dc.identifier.doi10.1016/j.ijbiomac.2024.132521
dc.identifier.endpage14
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid38772457
dc.identifier.scopus2-s2.0-85193747192
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1016/j.ijbiomac.2024.132521
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6850
dc.identifier.volume271
dc.identifier.wosWOS:001264340200001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBal-Öztürk, Ayça
dc.institutionauthorİzbudak, Burçin
dc.institutionauthoridAyça Bal Öztürk / 0000-0002-6502-528X
dc.institutionauthoridBurçin İzbudak / 0000-0002-5572-7966
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational journal of biological macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCMC
dc.subjectrGO
dc.subjectWound Dressing
dc.titleThe comparison of contribution of GO and rGO produced by green synthesis to the properties of CMC-based wound dressing material
dc.typeArticle

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