Prostate tissue ablation and drug delivery by an image-guided injectable ionic liquid in ex vivo and in vivo models

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dc.authorscopusidŞeyda Gündüz / 53879546000
dc.authorwosidŞeyda Gündüz / FCD-5483-2022
dc.contributor.authorDemirlenk, Yusuf M.
dc.contributor.authorAlbadawi, Hassan
dc.contributor.authorZhang, Zefu
dc.contributor.authorAtar, Dila
dc.contributor.authorÇevik, Enes
dc.contributor.authorKeum, Hyeongseop
dc.contributor.authorKim, Jinjoo
dc.contributor.authorRehman, Suliman
dc.contributor.authorGündüz, Şeyda
dc.contributor.authorGraf, Erin
dc.contributor.authorMayer, Joseph L.
dc.contributor.authorDos Santos, Pedro R.
dc.contributor.authorOklu, Rahmi
dc.date.accessioned2025-04-18T10:26:15Z
dc.date.available2025-04-18T10:26:15Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractBenign prostatic hyperplasia and prostate cancer are often associated with lower urinary tract symptoms, which can severely affect patient quality of life. To address this challenge, we developed and optimized an injectable compound, prostate ablation and drug delivery agent (PADA), for percutaneous prostate tissue ablation and concurrently delivered therapeutic agents. PADA is an ionic liquid composed of choline and geranic acid mixed with anticancer therapeutics and a contrast agent. The PADA formulation was optimized for mechanical properties compatible with hand injection, diffusion capability, cytotoxicity against prostate cells, and visibility of an x-ray contrast agent. PADA also exhibited antibacterial properties against highly resistant clinically isolated bacteria in vitro. Ultrasound-guided injection, dispersion of PADA in the tissue, and tissue ablation were tested ex vivo in healthy porcine, canine, and human prostates and in freshly resected human tumors. In vivo testing was conducted in a murine subcutaneous tumor model and in the canine prostate. In all models, PADA decreased the number of viable cells in the region of dispersion and supported the delivery of nivolumab throughout a portion of the tissue. In canine survival experiments, there were no adverse events and no impact on urination. The injection approach was easy to perform under ultrasound guidance and produced a localized effect with a favorable safety profile. These findings suggest that PADA is a promising therapeutic prostate ablation strategy to treat lower urinary tract symptoms.
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA
dc.identifier.citationDemirlenk, Y. M., Albadawi, H., Zhang, Z., Atar, D., Cevik, E., Keum, H., ... & Oklu, R. (2024). Prostate tissue ablation and drug delivery by an image-guided injectable ionic liquid in ex vivo and in vivo models. Science translational medicine, 16(754), eadn7982.
dc.identifier.doi10.1126/scitranslmed.adn7982
dc.identifier.issn1946-6234
dc.identifier.issn1946-6242
dc.identifier.issue754
dc.identifier.pmid38959326
dc.identifier.scopus2-s2.0-85197698040
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1126/scitranslmed.adn7982
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7069
dc.identifier.volume16
dc.identifier.wosWOS:001262431000004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGündüz, Şeyda
dc.language.isoen
dc.publisherAmerican association advancement science
dc.relation.ispartofScience translational medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectUrinary-Tract Symptoms
dc.subjectQuality of Life
dc.subjectAndrogen-Deprivation
dc.subjectCancer
dc.subjectHyperplasia
dc.subjectCholine
dc.subjectTherapy
dc.titleProstate tissue ablation and drug delivery by an image-guided injectable ionic liquid in ex vivo and in vivo models
dc.typeArticle

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