Therapeutic potential of stromal vascular fraction in enhancing wound healing: a preclinical study

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dc.authorscopusidHuri Dedeakayoğulları / 57191334242
dc.authorwosidHuri Dedeakayoğulları / IWR-0215-2023
dc.contributor.authorHekimoğlu, Emine Rümeysa
dc.contributor.authorEşrefoğlu, Mukaddes
dc.contributor.authorÇimen, Fatma Bedia Karakaya
dc.contributor.authorPasin, Özge
dc.contributor.authorDedeakayoğulları, Huri
dc.date.accessioned2025-04-16T13:26:07Z
dc.date.available2025-04-16T13:26:07Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Rektörlük, Temel Bilimler Bölümü
dc.description.abstractBackgroundAdipose tissue provides an abundant source of stromal vascular fraction (SVF) cells for immediate administration. It can also give rise to many multipotent adipose-derived stromal cells. SVF is the population of cells obtained from mechanical or enzymatic digestion of lipoaspirate with no necessity for cell culture or expansion. Recently, the heterogeneous cell population found in the SVF gained wide-ranging translational significance in regenerative medicine.MethodsForty-eight male rats were randomly divided into two main groups, including the control and SVF groups. Each group was further divided into four groups as follows: 0th-, 3rd-, 7th-, and 10th-day groups. A skin excision of 1 x 1 cm covering the epidermis and dermis was performed on the back skin. Just after the wound was created, a subepidermal injection of SVF was applied. SVF was obtained from human adipose tissue using Lipocube SVFTM. On the 0th (1 h after the injections), 3rd, 7th, and 10th days, rats were killed, and skin excisions from the wound areas tissues were performed. Histopathological, biochemical, and western blotting analyses were performed on tissues.ResultsOur data showed that SVF obtained from a healthy woman improved wound healing in healthy rats. SVF has promoted wound healing mainly because of its antioxidant, antiapoptotic, and fibroblast/myofibroblast stimulating effects. SVF stimulated collagen production and contraction of the wound lips, supporting the closure.ConclusionsOur study provides additional data about the efficacy and pathophysiological and molecular mechanisms of the action of SVF on wound healing in healthy subjects. Our study is an experimental animal study.No Level AssignedThis journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
dc.description.sponsorshipBezmialem Vakıf Üniversitesi
dc.identifier.citationHekimoglu, E. R., Esrefoglu, M., Cimen, F. B. K., Pasin, Ö., & Dedeakayogullari, H. (2024). Therapeutic Potential of Stromal Vascular Fraction in Enhancing Wound Healing: A Preclinical Study. Aesthetic Plastic Surgery, 1-16.
dc.identifier.doi10.1007/s00266-024-04554-5
dc.identifier.issn0364-216X
dc.identifier.issn1432-5241
dc.identifier.pmid39681692
dc.identifier.scopus2-s2.0-85212180618
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1007/s00266-024-04554-5
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6022
dc.identifier.wosWOS:001378350500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDedeakayoğulları, Huri
dc.institutionauthoridHuri Dedeakayoğulları / 0000-0003-2706-9625
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofAesthetic plastic surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMesenchymal Stem Cell
dc.subjectPathophysiology
dc.subjectStromal Vascular Fraction
dc.subjectWound Healing
dc.titleTherapeutic potential of stromal vascular fraction in enhancing wound healing: a preclinical study
dc.typeArticle

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