Comparison of Bordetella pertussis Antibody Levels in Pregnant Women and Umbilical Cord Blood: A Multicenter Study

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dc.authorscopusidMurat Sütçü / 55499199300
dc.authorwosidMurat Sütçü / AAR-5212-2020
dc.contributor.authorNepesov, Merve İşeri
dc.contributor.authorKılıç, Halime
dc.contributor.authorYıldırım, Şükran
dc.contributor.authorGüleç, Sevgi
dc.contributor.authorKara, Yalçın
dc.contributor.authorKızıl, Mahmut Can
dc.contributor.authorKarbuz, Adem
dc.contributor.authorTerek, Demet
dc.contributor.authorSütçü, Murat
dc.contributor.authorTufan, Ergün
dc.contributor.authorDinleyici, Meltem
dc.contributor.authorKurugöl, Zafer
dc.contributor.authorKılıç, Ömer
dc.contributor.authorDinleyici, Ener Çağrı
dc.date.accessioned2025-04-18T07:06:41Z
dc.date.available2025-04-18T07:06:41Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground: In countries where pertussis vaccination is not administered during pregnancy, the determination of pertussis antibody levels in pregnant women is very important in terms of knowing the current seroepidemiology and potential strategies for immunizations. Methods: We included 396 pregnant women who were admitted to 4 different obstetrics and gynecology clinics. Anti-Bordetella pertussis toxin (PT) IgG and anti-Bordetella pertussis filamentous hemagglutinin IgG levels in maternal and cord blood pairs were determined by the ELISA method. Results: Venous blood serum anti-PT level was below 5 IU/mL in 58.8%, 5-40 IU/mL in 34.8%, 40-100 IU/mL in 5.1% and >100 IU/mL in 1.3% of pregnant women. Cord blood serum anti-PT level was below 5 IU/mL in 47.7%, 5-40 IU/mL in 44.5%, 40-100 IU/mL in 6.8% and >100 IU/mL in 1% of pregnant women. In our study, the anti-PT level was found below 40 IU/mL in 93.6% of pregnant women and 92.2% of cord blood. Our study found the anti-filamentous hemagglutinin level below 40 IU/mL in 81% of pregnant women and 66.2% of cord blood. Conclusions: Although it is known that pertussis causes serious morbidity and mortality in young infants all over the world and that the most effective and reliable way to prevent it is vaccination of pregnant women, it is a remarkable contradiction that pertussis vaccination rates and therefore seropositivity rates in pregnant women are very low.
dc.identifier.citationNepesov, M. I., Kilic, H., Yildirim, S., Gulec, S., Kara, Y., Kizil, M. C., ... & Dinleyici, E. C. (2024). Comparison of Bordetella pertussis Antibody Levels in Pregnant Women and Umbilical Cord Blood: A Multicenter Study. The Pediatric Infectious Disease Journal, 43(6), e201-e203.
dc.identifier.doi10.1097/INF.0000000000004298
dc.identifier.endpage203
dc.identifier.issn0891-3668
dc.identifier.issn1532-0987
dc.identifier.issue6
dc.identifier.pmid38451894
dc.identifier.scopus2-s2.0-85193510458
dc.identifier.scopusqualityQ1
dc.identifier.startpage201
dc.identifier.urihttp://dx.doi.org/10.1097/INF.0000000000004298
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6419
dc.identifier.volume43
dc.identifier.wosWOS:001281974100014
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSütçü, Murat
dc.institutionauthoridMurat Sütçü / 0000-0002-2078-9796
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofPediatric Infectious Disease Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNewborn
dc.subjectPertussis
dc.subjectPregnancy
dc.subjectVaccination
dc.titleComparison of Bordetella pertussis Antibody Levels in Pregnant Women and Umbilical Cord Blood: A Multicenter Study
dc.typeArticle

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