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Functionalized liposomes and niosomes for cancer therapy
(Elsevier, 2024) Yavari, Maryam; Sarrami Foroushani, Elnaz; Nasri, Negar; Zarepour, Atefeh; Zarrabi, Ali; Mostafavi, Ebrahim
Liposomes and niosomes are two members of lipid-based nanocarriers superfamily that have attracted lots of attention in the cancer therapy subject due to their interesting structural features. They are vesicular nanoparticles composed of cholesterol and phospholipid (liposomes) or surfactant (niosomes) that have the most similarity with cellular membranes and have the capability of loading both hydrophobic and hydrophilic therapeutic agents. Moreover, the surface of these carriers could be functionalized with different compounds to enhance their stability, bioavailability, and targeting ability, which finally could lead to improved therapeutic performance. This book chapter aims to discuss functionalized liposomal and niosomal therapeutic nanoparticles for cancer treatment. To this end, we will first describe different structural features of liposomes and niosomes and their different preparation methods. Then we will mention different generations of liposomes and niosomes as well as different types of functionalization that could affect the stability, loading capacity, and bioavailability of these carriers in targeted cancer tissue. © 2024 Elsevier Inc. All rights reserved.