Comparative effect of ostrich, olive, and omega-3 oils in the prevention of liver damage due to ionizing radiation in rats

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dc.authorscopusidHüseyin Ozan Tekin / 56971130700
dc.authorwosidHüseyin Ozan Tekin / J-9611-2016
dc.contributor.authorElmas, Özlem
dc.contributor.authorŞahin, Havva Hande Keser
dc.contributor.authorGüven, Berrak
dc.contributor.authorAlmisned, Ghada
dc.contributor.authorZakaly, Hesham M. H.
dc.contributor.authorTekin, Hüseyin Ozan
dc.contributor.authorEne, Antoaneta
dc.date.accessioned2025-04-17T10:21:14Z
dc.date.available2025-04-17T10:21:14Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Bilgisayar Mühendisliği Bölümü
dc.description.abstractThe objective of this study was to assess the potential advantageous impact of ostrich oil, olive oil, and omega-3 oil in mitigating the oxidative stress and hepatic tissue damage induced by ionizing radiation in rats. A total of sixty-four female Wistar albino rats were categorized into eight distinct groups, namely: (1) control, (2) irradiation, (3) ostrich oil, (4) ostrich oil combined with irradiation, (5) olive oil, (6) olive oil combined with irradiation, (7) omega-3, and (8) omega-3 combined with irradiation. Omega-3 oil treatment resulted in decreased levels of tissue total oxidant status (TOS) in both healthy and irradiated animals. The study revealed that the rats subjected to radiation and administered with ostrich oil and omega-3 exhibited the lowest levels of tissue total antioxidant status (TAS). The group that was exposed to radiation exhibited significant levels of lymphocyte infiltration, 70% of the samples displaying this characteristic. Additionally, 40% of the samples exhibited ballooning degeneration at the most severe levels, while 60% displayed necrotic changes at a severe level. The animals that were administered omega-3 oil exhibited the least amount of lymphocyte infiltration, ballooning degeneration, and necrotic changes among the groups that were exposed to radiation. The administration of ostrich oil, olive oil, and omega-3 oil at a concentration of 1 mL/kg before exposure to radiation resulted in a reduction of TOS and the restoration of liver morphology. The results of the study indicate that the administration of olive oil to animals resulted in the highest levels of antioxidant activity in irradiated rats. Additionally, rats that received omega-3 oil exhibited the lowest levels of lymphocyte infiltration, ballooning degeneration, and necrosis in liver tissue sections.
dc.description.sponsorshipDunarea de Jos University of Galati, Romania
dc.identifier.citationElmas, O., Sahin, H. H. K., Guven, B., ALMisned, G., Zakaly, H. M., Tekin, H. O., & Ene, A. (2025). Comparative effect of ostrich, olive, and Omega-3 oils in the prevention of liver damage due to ionizing radiation in rats. Journal of Radiation Research and Applied Sciences, 18(1), 101321.
dc.identifier.doi10.1016/j.jrras.2025.101321
dc.identifier.endpage10
dc.identifier.issn1687-8507
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.urihttp://dx.doi.org/10.1016/j.jrras.2025.101321
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6189
dc.identifier.volume18
dc.identifier.wosWOS:001410028200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.institutionauthorTekin, Hüseyin Ozan
dc.institutionauthoridHüseyin Ozan Tekin / 0000-0002-0997-3488
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of radiation research and applied sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectOxidative Stress
dc.subjectRadioprotection
dc.subjectOstrich Oil
dc.subjectOlive Oil
dc.subjectFish Oil
dc.titleComparative effect of ostrich, olive, and omega-3 oils in the prevention of liver damage due to ionizing radiation in rats
dc.typeArticle

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