The potential of nanocomposites (patuletin-conjugated with gallic acid-coated zinc oxide) against free-living amoebae pathogens

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dc.authorscopusidRuqaiyyah Siddiqui / 18635417000
dc.authorscopusidNaveed Ahmed Khan / 7401797675
dc.authorwosidRuqaiyyah Siddiqui / AIF-2100-2022
dc.authorwosidNaveed Ahmed Khan / GWD-0187-2022
dc.contributor.authorSiddiqui, Ruqaiyyah
dc.contributor.authorKhatoon, Bushra
dc.contributor.authorKawish, Muhammad
dc.contributor.authorSajeev, Sreedevi
dc.contributor.authorFaizi, Shaheen
dc.contributor.authorShah, Muhammad Raza
dc.contributor.authorAlharbi, Ahmad M.
dc.contributor.authorKhan, Naveed Ahmed
dc.date.accessioned2025-04-16T11:26:58Z
dc.date.available2025-04-16T11:26:58Z
dc.date.issued2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractFree-living amoebae infections are on the rise while the prognosis remains poor. Current therapies are ineffective, and there is a need for novel effective drugs which can target Naegleria, Balamuthia, and Acanthamoeba species. In this study, we determined the effects of a nano-formulation based on flavonoid patuletin-loaded gallic acid functionalized zinc oxide nanoparticles (PA-GA-ZnO) against Acanthamoeba, Balamuthia, and Naegleria trophozoites. Characterization of the nano-formulation was accomplished utilizing analytical tools, namely Fourier-transform infrared spectroscopy, drug entrapment efficiency, polydispersity index, dimensions, and surface morphologies. Anti-amoebic effects were investigated using amoebicidal assay, cytopathogenicity assay, and cytotoxicity of the nano-formulation on human cells. The findings revealed that nano-formulation (PA-GA-ZnO) displayed significant anti-amoebic properties and augmented effects of patuletin alone against all three brain-eating amoebae. When tested alone, patuletin nano-formulations showed minimal toxicity effects against human cells. In summary, the nano-formulations evaluated herein depicts efficacy versus Acanthamoeba, Balamuthia, and Naegleria. Nonetheless, future studies are needed to comprehend the molecular mechanisms of patuletin nano-formulations versus free-living amoebae pathogens, in addition to animal studies to determine their potential value for clinical applications.
dc.description.sponsorshipAir Force Office of Scientific Research Taif University
dc.identifier.citationSiddiqui, R., Khatoon, B., Kawish, M., Sajeev, S., Faizi, S., Shah, M. R., ... & Khan, N. A. (2024). The potential of nanocomposites (patuletin-conjugated with gallic acid-coated zinc oxide) against free-living amoebae pathogens. International Microbiology, 1-11.
dc.identifier.doi10.1007/s10123-024-00584-w
dc.identifier.issn1139-6709
dc.identifier.issn1618-1905
dc.identifier.scopus2-s2.0-85204102953
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.1007/s10123-024-00584-w
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6005
dc.identifier.wosWOS:001313425700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSiddiqui, Ruqaiyyah
dc.institutionauthorKhan, Naveed Ahmed
dc.institutionauthoridRuqaiyyah Siddiqui / 0000-0001-9646-6208
dc.institutionauthoridNaveed Ahmed Khan / 0000-0001-7667-8553
dc.language.isoen
dc.publisherSpringer science and business media deutschland GmbH
dc.relation.ispartofInternational microbiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcanthamoeba
dc.subjectAnti-Amoebic
dc.subjectBalamuthia
dc.subjectCentral Nervous System Infections
dc.subjectNanocomposite
dc.subjectNanotechnology
dc.subjectPatuletin-Zinc Oxide
dc.titleThe potential of nanocomposites (patuletin-conjugated with gallic acid-coated zinc oxide) against free-living amoebae pathogens
dc.typeArticle

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