Sustained release investigation of curcumin and ciprofloxacin on coaxial electrospun nanocomposite scaffold of poly (3-hydroxybutyrate)-poly glycerol sebacate: an approach for skin regeneration

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dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019
dc.contributor.authorHosseini, Seyed Mohammad Reza
dc.contributor.authorHeydari, Parisa
dc.contributor.authorAzadani, Reyhaneh Nasr
dc.contributor.authorIravani, Siavash
dc.contributor.authorZarrabi, Ali
dc.date.accessioned2025-06-18T12:04:20Z
dc.date.available2025-06-18T12:04:20Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractThe utilization of biomaterial scaffolds may promote the regeneration of cutaneous wounds. The investigation focused on fabricating an innovative type of scaffold for skin tissue regeneration through the coaxial electrospinning technique. The scaffold consisted of two segments: the core layer accommodated a combination of polyglycerol sebacate (PGS) and curcumin (Cur), while the shell layer contained poly(3-hydroxybutyrate) (PHB) and ciprofloxacin (CIP). An evaluation was conducted on the physical and mechanical properties, drug release characteristics, and cellular responses of the scaffolds. The assessment revealed that the fiber diameters and porosity of PGS/PHB and PGS/PHB-Cur/CIP were measured at 400-480 nm and 83-86%, respectively. The transmission electron microscopy (TEM) findings exhibited distinct core and shell structures in the PGS/PHB-Cur/CIP specimens. The specific aspects of the PGS/PHB-Cur/CIP scaffold, such as its controlled degradation (below 50% over 21 days), sustained drug release behavior of Cur and CIP (over 5 days), and optimal strength attributes (stress strength similar to 0.104 MPa), differentiate it from traditional wound coverings. Specifically, the incorporation of CIP and Cur into the fiber configuration enhanced the viability and adhesion of cells, resulting in an appropriate morphology. Therefore, the coaxial PGS/PHB-Cur/CIP demonstrates a heightened potential for wound dressing application or as a skin substitute.
dc.identifier.citationHosseini, S. M. R., Heydari, P., Azadani, R. N., Iravani, S., & Zarrabi, A. (2024). Sustained release investigation of curcumin and ciprofloxacin on coaxial electrospun nanocomposite scaffold of poly (3-hydroxybutyrate)-poly glycerol sebacate: an approach for skin regeneration. Emergent Materials, 1-12.
dc.identifier.doi10.1007/s42247-024-00874-z
dc.identifier.endpage516
dc.identifier.issn2522-5731
dc.identifier.issn2522-574X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-105001067657
dc.identifier.scopusqualityQ1
dc.identifier.startpage505
dc.identifier.urihttp://dx.doi.org/10.1007/s42247-024-00874-z
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7308
dc.identifier.volume8
dc.identifier.wosWOS:001328524500002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorZarrabi, Ali
dc.institutionauthoridAli Zarrabi / 0000-0003-0391-1769
dc.language.isoen
dc.publisherSpringer nature
dc.relation.ispartofEmergent materials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCiprofloxacin (CIP)
dc.subjectCoaxial Electrospinning
dc.subjectCurcumin (Cur)
dc.subjectPoly(3-hydroxybutyrate) (PHB)
dc.subjectPolyglycerol Sebacate (PGS)
dc.titleSustained release investigation of curcumin and ciprofloxacin on coaxial electrospun nanocomposite scaffold of poly (3-hydroxybutyrate)-poly glycerol sebacate: an approach for skin regeneration
dc.typeArticle

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