High malignancy rate in IgE-deficient children

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dc.authorscopusidVedat Uygun / 10043117000
dc.authorwosidVedat Uygun / AGH-4534-2022
dc.contributor.authorUygun, Dilara Fatma Kocacık
dc.contributor.authorUygun, Vedat
dc.contributor.authorBaşaran, Ayşen
dc.contributor.authorKocatepe, Gaye
dc.contributor.authorKazlı, Tuğba
dc.contributor.authorBingöl, Ayşen
dc.date.accessioned2025-04-18T06:44:39Z
dc.date.available2025-04-18T06:44:39Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractRecent epidemiological studies have increasingly highlighted the antitumor efficacy of IgE owing to the increased malignancy rate in IgE-deficient patients. The purpose of this study, the largest for children, was to determine whether malignant diagnoses in children are associated with IgE deficiency (IgE <2.5 kIU/L). A total of 6821 pediatric patients were reviewed, focusing on patients with IgE below 2.5 kIU/L (n = 599). The causes of IgE testing were evaluated by categorizing them as having cancer, allergies, suspected or diagnosed immunodeficiency, and other conditions. In all but one patient with malignancy, IgE levels were measured after the diagnosis of the disease. Malignancies were observed much more frequently in the low IgE group than in the normal group (10/599, 1.7% and 7/6222, 0.11%; OR = 15.07; 95% CI: 5.72-39.75; p <.0001). According to our analysis, 70% of the patients had leukemia/lymphoma, which is consistent with studies showing that hematologic malignancies are the most frequent cancers linked to IgE deficiency. No increase in the prevalence of cancer was observed in IgE-deficient patients with suspected or diagnosed immunodeficiency. In conclusion, we observed a higher rate of previous malignancy (particularly hematologic cancer) in children with low serum IgE levels. Larger investigations would offer insightful information about the function of low IgE levels in predicting malignancy risk and improving the present diagnostic procedures.
dc.identifier.citationUygun, D. F. K., Uygun, V., Başaran, A., Kocatepe, G., Kazlı, T., & Bingöl, A. (2025). High malignancy rate in IgE‐deficient children. International Journal of Cancer, 156(5), 964-968.
dc.identifier.doi10.1002/ijc.35213
dc.identifier.endpage968
dc.identifier.issn0020-7136
dc.identifier.issn1097-0215
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85205917015
dc.identifier.scopusqualityQ1
dc.identifier.startpage964
dc.identifier.urihttp://dx.doi.org/10.1002/ijc.35213
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6361
dc.identifier.volume156
dc.identifier.wosWOS:001329201700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorUygun, Vedat
dc.institutionauthoridVedat Uygun / 0000-0003-3257-7798
dc.language.isoen
dc.publisherJohn wiley and sons inc
dc.relation.ispartofInternational journal of cancer
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAllergy
dc.subjectChildren
dc.subjectIgE
dc.subjectImmunodeficiency
dc.subjectMalignancy
dc.titleHigh malignancy rate in IgE-deficient children
dc.typeArticle

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