Brentuximab Vedotin Monotherapy in Relapsed/Refractory T Cell Lymphoma Setting-Real Life Data
Küçük Resim Yok
Tarih
23.07.2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Hitit Üniverstesi Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: We present data of patients with relapsed/ refractory T cell lymphomas treated with brentuximab vedotin (BV) in real-world practice. Material and Method: This study is an observational, multi-center, retrospective study. The data of patients (n=17) treated with BV alone from January 2014 until July 2020 in thirteen centers from Turkey were collected. Results: Bv was given as salvage chemotherapy to 17 patients with median age of 53. Nine (52.9%) patients had diagnosis of peripheral T cell lymphoma, not otherwise specified; 8 (47.1%) patients had anaplastic large T cell lymphoma. The median follow-up of the cohort was 20 months. Nine (52.9%) patients had complete response, 5 (29.5%) had partial response, 3 (17.6%) had progressive disease. The safety results aligned with the established profile of BV, included 2 pneumonia and 1 thrombocytopenia with grade 4. The median progression free survival of the cohort was 10 months. BV cycle and response to BV therapy were found to have an effect on the univariate analysis. Conclusion: In patients with relapsed/ refractory T cell lymphomas, BV seems to have convincing antitumor activity with favorable safety profile.
Açıklama
Anahtar Kelimeler
brentuximab vedotin, relapse, T cell lymphoma
Kaynak
Hitit medical journal (Online)
WoS Q Değeri
Scopus Q Değeri
Cilt
6
Sayı
2
Künye
DARÇIN, T., SERIN, I., UGUR, M. C., EKINCI, O., YONAL-HINDILERDEN, I., AKPINAR, S., HACIBEKIROGLU, T., DEMIRCIOĞLU, S., GÜLTÜRK, E., ALBAYRAK, M., AYDOGDU, I., DAL, M. S., DOĞU, M. H., NAMDAROGLU, S., DOĞAN, A., NALCACI, M., TURGUT, B., BAŞCI, S., ALTUNTAS, F. (2024). Brentuximab Vedotin Monotherapy in Relapsed/Refractory T Cell Lymphoma Setting-Real Life Data. Hitit medical journal (Online) , 6(2), 186 - 192. doi.org/10.52827/hititmedj.1320606
