Central line-associated bloodstream infection outbreak related to Ralstonia pickettii-contaminated saline in a pediatric hematopoietic stem cell transplant center

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dc.authoridSafiye Suna Çelen / 0000-0002-7930-2081
dc.authoridSuleimen Zhumatayev / 0000-0002-4409-8180
dc.authoridKoray Yalçın / 0000-0003-3454-9870
dc.authoridEmine Manolya Kara / 0000-0001-6234-7024
dc.authoridMurat Sutcu / 0000-0002-2078-9796
dc.authoridGulsun Karasu / 0000-0001-5700-5919
dc.authoridM.Akif Yesilipek / 0000-0002-4514-8637
dc.authorscopusidMurat Sutcu / 55499199300
dc.authorwosidMurat Sutcu / ABG-7336-2021
dc.contributor.authorÇelen, Safiye Suna
dc.contributor.authorZhumatayev, Suleimen
dc.contributor.authorYalçın, Koray
dc.contributor.authorKara, Emine Manolya
dc.contributor.authorSutcu, Murat
dc.contributor.authorKarasu, Gulsun
dc.contributor.authorYesilipek, M.Akif
dc.date.accessioned2025-04-18T09:31:13Z
dc.date.available2025-04-18T09:31:13Z
dc.date.issued17.10.2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground. Ralstonia pickettii is an aerobic Gram-negative non-fermentative bacillus. It is an opportunistic pathogen that has recently prompted nosocomial outbreaks. Although it has low virulence, it can cause a wide range of invasive diseases in immunosuppressive patients. The characteristics of R. pickettii-related central line-associated bloodstream infection (CLABSI) outbreak in pediatric hematopoietic stem cell transplant (HSCT) recipients are presented in this study. Materials and Methods. This was a single-center, retrospective analysis conducted at Bahcesehir University Goztepe Medicalpark Hospital . The clinical and laboratory characteristics of twelve children with Ralstonia-related CLABSIs were analyzed. Results. Of the twelve patients with R. pickettii growth, seven were female. The median age was 12.1 (2-17) years. Autologous HSCT was performed in two of the patients and allogeneic HSCT was performed in ten patients for both malignant and non-malignant diseases. In the conditioning regimens, all patients were given myeloablative therapy. Clinical sepsis was the most common presentation. As a result of the investigations, R. pickettii growth was observed in saline solutions. All cases were successfully treated with the appropriate antibiotic regimen and the bacteria was not found in repeat cultures. Catheter removal was required in two patients. Mortality was not observed in any patient as the outcome of the infection episode. Conclusion. The detection and control of the infectious source are critical in pediatric HSCT patients with severe immunosuppression, as medical equipment-related outbreaks can be life-threatening.
dc.identifier.citationÇELEN, S. . S., ZHUMATAYEV, S., YALÇIN, K., KARA, E. M., SUTCU, M., KARASU, G., YESILIPEK, M. (2024). Central line-associated bloodstream infection outbreak related to Ralstonia pickettii-contaminated saline in a pediatric hematopoietic stem cell transplant center. Turkish Journal of Pediatrics , 66(4), 421 - 428. doi.org/10.24953/turkjpediatr.2024.4529
dc.identifier.doi10.24953/turkjpediatr.2024.4529
dc.identifier.endpage428
dc.identifier.issn0041-4301
dc.identifier.issue4
dc.identifier.pmid39387430
dc.identifier.scopus2-s2.0-85206278466
dc.identifier.scopusqualityQ3
dc.identifier.startpage421
dc.identifier.trdizinid1268915
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1268915/central-line-associated-bloodstream-infection-outbreak-related-to-ralstonia-pickettii-contaminated-saline-in-a-pediatric-hematopoietic-stem-cell-transplant-center
dc.identifier.urihttps://doi.org/10.24953/turkjpediatr.2024.4529
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6810
dc.identifier.volume66
dc.identifier.wosWOS:001335682800004
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.institutionauthorSutcu, Murat
dc.institutionauthoridMurat Sutcu / 0000-0002-2078-9796
dc.language.isotr
dc.publisherHacettepe Üniversitesi Çocuk Sağlığı Enstitüsü Müdürlüğü
dc.relation.ispartofTurkish Journal of Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRalstonia pickettii
dc.subjectstem cell transplantation
dc.subjectchild
dc.subjectoutbreak
dc.subjectinfectious disease
dc.titleCentral line-associated bloodstream infection outbreak related to Ralstonia pickettii-contaminated saline in a pediatric hematopoietic stem cell transplant center
dc.typeArticle

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