The Corpus Callosum in Schizoaffective Disorder: A Shape Analysis Study

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dc.authoridÖzlem Gül / 0000-0003-1236-0348
dc.authoridSema Baykara / 0000-0002-4683-0945
dc.authoridMustafa Nuray Namlı / 0000-0001-9778-4216
dc.authoridMurat Baykara / 0000-0003-2588-9013
dc.authorscopusidÖzlem Gül / 57223989661
dc.authorwosidÖzlem Gül / HJA-7712-2022
dc.contributor.authorGül, Özlem
dc.contributor.authorBaykara, Sema
dc.contributor.authorNamlı, Mustafa Nuray
dc.contributor.authorBaykara, Murat
dc.date.accessioned2025-04-18T06:50:49Z
dc.date.available2025-04-18T06:50:49Z
dc.date.issued30 Eylül 2024
dc.departmentİstinye Üniversitesi, İnsan ve Toplum Bilimleri Fakültesi, Psikoloji Bölümü
dc.description.abstractObjective: The corpus callosum is the largest white matter structure in the human brain that connects the cortical regions of both hemispheres. Diseases could lead to degenerative alterations in brain structures such as the corpus callosum (CC). Studies have associated CC abnormalities with Schizoaffective Disorder (SAD) symptoms. We predicted that there may be differences in the CC, an important structure connecting the two halves of the brain, in patients with SAD. The present study aims to analyze the CC of patients with statistical shape analysis (SSA) and compare the findings with healthy controls. Methods: Thirty-nine SAD patients and 39 healthy individuals (11 females and 28 males) of similar age that included subjects participated in the study. CC landmarks were marked on the mid-sagittal images of each participant. The mean ‘Procrustes’ point was determined, and shape deformations were analyzed with thin plate spline analysis. Results: Significant differences were observed between the shapes of CC in the two groups, and maximum CC deformation was observed in the posterior regions of SAD patients. There was no significant difference between the CC area of the SAD patients and the controls. Conclusion: In the present study, the maximum deformation was observed in the posterior region (isthmus and splenium) and the rostrum of the CC. The first CC region, the rostrum (+genu), connects prefrontal and premotor regions, which are associated with cognitive information (landmarks = 1, 7, 8, 9, 13, 15, and 12). The second area, the splenium, connects temporal and occipital cortical areas. These predominantly have auditory, peripheral, and central visual stimulation functions (landmarks = 5, 3, and 4). The current study could assist future studies on the etiology, diagnosis, and treatment of SAD.
dc.identifier.citationGül, Ö., Baykara, S., Namlı, M. N., Baykara, M. (2024). The Corpus Callosum in Schizoaffective Disorder: A Shape Analysis Study. Clinical and Experimental Health Sciences, 14(3), 691-697. https://doi.org/10.33808/clinexphealthsci.1323653
dc.identifier.doi10.33808/clinexphealthsci.1323653
dc.identifier.endpage697
dc.identifier.issue3
dc.identifier.startpage691
dc.identifier.trdizinid1267980
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.1323653
dc.identifier.urihttps://dergipark.org.tr/en/pub/clinexphealthsci/issue/87387/1323653
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6379
dc.identifier.volume14
dc.identifier.wosWOS:001340200900008
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorGül, Özlem
dc.institutionauthoridÖzlem Gül / 0000-0003-1236-0348
dc.language.isoen
dc.publisherMarmara University
dc.relation.ispartofClinical and Experimental Health Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCorpus callosum
dc.subjectschizoaffective disorder
dc.subjectmagnetic resonance imaging
dc.subjectneuroimaging
dc.subjectcomputer-assisted imaging.
dc.titleThe Corpus Callosum in Schizoaffective Disorder: A Shape Analysis Study
dc.typeArticle

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