A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?

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dc.authoridHazal Eken / 0000-0003-2360-511X
dc.authoridNurcan Bektaş / 0000-0003-2597-6184
dc.authorwosid
dc.contributor.authorEken, Hazal
dc.contributor.authorBektaş, Nurcan
dc.date.accessioned2025-05-30T12:21:26Z
dc.date.available2025-05-30T12:21:26Z
dc.date.issued2022
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractPain is sensed by the activation of painful nociceptors in the periphery or by pain mediators, such as bradykinin, serotonin, histamine, and prostaglandin, released from the damaged tissue, afferent transmission to the medulla spinalis, and by trans- mission stages to the high centers over the dorsal horn. Pain, which was seen as only a warning sign in the past, is now ac- cepted as a phenomenon in itself that needs to be treated and the search for new, stronger active substances with fewer side effects in the treatment of pain is in demand. Hydrogen sulfide (H 2S) is a modulator of T-type Ca+2 channels, especially in Cav3.2, which are known to play a critical role in the processing of pain. H2S can also show an anti-nociceptive effect by open- ing K + channels and blocking nociceptors. Exciting preclinical data has demonstrated that H2S-derived Non-steroidal anti- inflammatory drugs (NSAIDs) and analgesic agents can be used to treat various types of pain. H2S increases the resistance of gastric mucosa against injury occurred by drugs used for pain relief and accelerates its repair, so it provides an advantage to derivatized drugs. In addition, H2S donors have also been shown to induce analgesia through μ-opioid receptors. Based on the studies, it is thought that the combination of H2S with opioid receptor agonists may provide an additive or even synergistic analgesic effect. It is estimated that the modification of H2S, with currently used analgesic drugs to prevent various side ef- fects and increase analgesic effects, is a promising and wise approach.
dc.identifier.citationEKEN, H., BEKTAS, N. (2022). A review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?. Istanbul Journal of Pharmacy , 52(1), 101 - 107.
dc.identifier.doi10.26650/IstanbulJPharm.2022.913936
dc.identifier.endpage107
dc.identifier.issn2548-0731
dc.identifier.issue1
dc.identifier.scopuseid=2-s2.0-84979917789
dc.identifier.scopusqualityQ1
dc.identifier.startpage101
dc.identifier.trdizinid1127043
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1127043/a-review-on-hydrogen-sulfide-is-it-pro-nociceptive-or-anti-nociceptive
dc.identifier.urihttps://hdl.handle.net/20.500.12713/7262
dc.identifier.volume52
dc.identifier.wosWOS:000793925000015
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorEken, Hazal
dc.institutionauthoridHazal Eken / 0000-0003-2360-511X
dc.language.isoen
dc.publisherİstanbul Üniversitesi Yayınevi
dc.relation.ispartofIstanbul Journal of Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleA review on hydrogen sulfide: Is it pro-nociceptive or anti-nociceptive?
dc.typeArticle

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