Factors Determining Lymph Node Metastasis in Patients with Early Stage Non-Squamous Cell Cervical Carcinoma

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dc.authoridFatih Kılıç / 0000-0002-7333-4883
dc.authoridGülşah Tiryaki / 0000-0003-4543-1763
dc.authoridMert İshak Kaya / 0000-0001-6258-7597
dc.authoridMelih Emre Torun / 0009-0006-2004-6710
dc.authoridOkan Oktar / 0000-0002-9696-7886
dc.authoridNecim Yalçın / 0000-0001-5980-3244
dc.authoridİlker Selcuk / 0000-0003-0499-5722
dc.authoridCaner Çakır / 0000-0003-2559-9104
dc.authoridÇiğdem Kılıç / 0000-0002-4433-8068
dc.authoridGünsu Kimyon Cömert / 0000-0003-0178-4196
dc.authoridİsin Ureyen / 0000-0002-3491-4682
dc.authoridNurettin Boran / 0000-0002-0367-5551
dc.authoridVakkas Korkmaz / 0000-0001-8895-6864
dc.authoridTayfun Toptaş / 0000-0002-6706-6915
dc.authoridDerman Basaran / 0000-0002-2689-1417
dc.authoridAlper Karalök / 0000-0002-0059-8773
dc.authoridTolga Taşçı / 0009-0001-7904-6890
dc.authoridTaner Turan / 0000-0001-8120-1143
dc.authorwosidAlper Karalök / AHB-8790-2022
dc.contributor.authorKılıç, Fatih
dc.contributor.authorTiryaki, Gülşah
dc.contributor.authorKaya, Mert İshak
dc.contributor.authorTorun, Melih Emre
dc.contributor.authorOktar, Okan
dc.contributor.authorYalçın, Necim
dc.contributor.authorSelcuk, İlker
dc.contributor.authorÇakır, Caner
dc.contributor.authorKılıç, Çiğdem
dc.contributor.authorCömert, Günsu Kimyon
dc.contributor.authorUreyen, İsin
dc.contributor.authorBoran, Nurettin
dc.contributor.authorKorkmaz, Vakkas
dc.contributor.authorToptaş, Tayfun
dc.contributor.authorBasaran, Derman
dc.contributor.authorKaralök, Alper
dc.contributor.authorTaşçı, Tolga
dc.contributor.authorTuran, Taner
dc.date.accessioned2025-04-18T06:42:03Z
dc.date.available2025-04-18T06:42:03Z
dc.date.issued1 Nisan 2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractAim: To evaluate the clinical and pathological characteristics of early stage non-squamous cell cervical carcinoma (non-SCCC) patients and identify factors that predict lymph node metastasis. Materials and method: Patients who underwent radical hysterectomy plus lymphadenectomy for stage IB1-IIA2 non-SCCC between 1993 and 2022 in six gynecologic oncology centers were included in this retrospective study. The effects of the risk factors on lymph node metastasis were evaluated by using univariate and multivariate logistic regression analysis. Results: The study involved 126 patients with a median age of 48 years (range, 26-77 years). According to FIGO 2009 staging, 91 patients (72.2%) were at stage IB1, 24 (19%) were at stage IB2, 9 (7.1%) were at stage IIA1, and 2 (1.6%) were at stage IIA2. Tumor subtype were adenocarcinoma in 93 (73.8%) patients and adenosquamous carcinoma in 28 (22.2%) patients. In univariate analysis; age, tumor size, stromal invasion, parametrial invasion, uterine involvement, lymphovascular space invasion (LVSI), vaginal involvement, and surgical border involvement were associated with lymph node metastasis. In multivariate analysis, LVSI (Hazard Ratio: 19.63, 95% Confidence Interval: 3.499-110.166; p=0.001) and uterine involvement (Hazard Ratio: 4.36, 95% Confidence Interval: 1.178-16.165; p=0.027) were identified as independent prognostic factors for lymph node metastasis. Conclusion: LVSI and uterine involvement were independent predictors of lymph node metastasis in early-stage non-SCCC patients. These factors can be identified with high accuracy in biopsy specimens and imaging methods in the preoperative period.
dc.identifier.citationKılıç, F., Tiryaki, G., Kaya, M. İ., Torun, M. E., Oktar, O., Yalçın, N., ... & Turan, T. (2024). Factors Determining Lymph Node Metastasis in Patients with Early Stage Non-Squamous Cell Cervical Carcinoma. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, 21(1), 1-7.
dc.identifier.doi10.38136/jgon.1396054
dc.identifier.endpage7
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.38136/jgon.1396054
dc.identifier.urihttps://dergipark.org.tr/tr/pub/jgon/issue/84044/1396054
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6351
dc.identifier.volume21
dc.institutionauthorKaralök , Alper
dc.institutionauthoridAlper Karalök / 0000-0002-0059-8773
dc.language.isoen
dc.publisherT.C. Sağlık Bakanlığı Ankara Şehir Hastanesi
dc.relation.ispartofJinekoloji - Obstetrik ve Neonatoloji Tıp Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLymph node metastasis
dc.subjectlymphovascular space invasion
dc.subjectnon-squamous cell cervical carcinoma
dc.subjectuterine involvement
dc.titleFactors Determining Lymph Node Metastasis in Patients with Early Stage Non-Squamous Cell Cervical Carcinoma
dc.title.alternativeErken Evre Non-squamoz Hücreli Serviks Kanserli Hastalarda Lenf Nodu Metastazını Belirleyen Faktörler
dc.typeArticle

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