Frequency and relationship of HLA allele in Turkish patients with Fanconi anemia

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dc.authoridBehnoush Nasr Zanjani / 0000-0001-6853-4410
dc.authoridHayriye Şentürk Çiftçi / 0000-0003-3507-482X
dc.authoridÇiğdem Kekik Çınar / 0000-0003-2098-381X
dc.authoridTülin Tiraje Celkan / 0000-0001-7287-1276
dc.authoridNevin Yalman / 0000-0002-8822-6615
dc.authoridFatma Savran Oğuz / 0000-0002-6018-8936
dc.authorscopusidTülin Tiraje Celkan / 35584411200
dc.authorwosidTülin Tiraje Celkan / AAI-1729-2019
dc.contributor.authorZanjani, Behnoush Nasr
dc.contributor.authorÇiftçi, Hayriye Şentürk
dc.contributor.authorÇınar, Çiğdem Kekik
dc.contributor.authorCelkan, Tülin Tiraje
dc.contributor.authorYalman, Nevin
dc.contributor.authorOğuz, Fatma Savran
dc.date.accessioned2025-04-18T06:36:40Z
dc.date.available2025-04-18T06:36:40Z
dc.date.issued30 Eylül 2024
dc.departmentİstinye Üniversitesi, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü
dc.description.abstractPurpose: Fanconi anemia (FA) is a childhood disorder inherited in an autosomal recessive manner. It is characterized by bone marrow failure, a range of congenital physical abnormalities, increased susceptibility to cancer, chromosomal instability, and heightened sensitivity to cross-linking agents. The aim of this study was to determine the role of the HLA Class I and Class II alleles in genetic susceptibility to Fanconi anemia in Turkish patients. Materials and Methods: In this study, we retrospectively evaluated the HLA-A, -B, and -DRB1 allele frequencies of patients with Fanconi anemia who underwent hematopoietic stem cell transplantation between 2010 and 2021. HLA-A, -B, -DR of all patients and healthy Turkish individuals were genotyped. Results: The study included 86 patients with Fanconi anemia and 300 healthy controls. The most common antigens in patients with Fanconi were HLA-A*02, HLA-B*35 and DRB1*11. Moreover, in the patient group, the HLA-A*23 allele was significantly lower than the control group. When we evaluated the patient group according to gender the HLA-A*01 allele was significantly higher in the female patient group. Conclusion: Our study provides valuable insights into the genetic susceptibility of Turkish patients with Fanconi anemia, focusing on the role of HLA Class I and Class II alleles. HLA-B*14 may be a risk factor and HLA-A*23 may be protective for Fanconi anemia. These results contribute to our understanding of the complex genetic factors underlying Fanconi anemia and may have implications for improved diagnosis, prognosis, and potential therapeutic interventions for affected individuals.
dc.identifier.citationZanjani, B. N., Çiftçi, H. Ş., Çınar, Ç. K., Celkan, T. T., Yalman, N., & Oğuz, F. S. Frequency and relationship of HLA allele in Turkish patients with Fanconi anemia. Cukurova Medical Journal, 49(3), 607-613.
dc.identifier.doi10.17826/cumj.1443687
dc.identifier.endpage613
dc.identifier.issn2602-3032
dc.identifier.issue3
dc.identifier.startpage607
dc.identifier.trdizinid1267238
dc.identifier.urihttps://doi.org/10.17826/cumj.1443687
dc.identifier.urihttps://dergipark.org.tr/en/pub/cumj/issue/87318/1443687
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6343
dc.identifier.volume49
dc.identifier.wosWOS:001329719100002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorCelkan, Tülin Tiraje
dc.institutionauthoridTülin Tiraje Celkan / 0000-0001-7287-1276
dc.language.isoen
dc.publisherCukurova University
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFanconi anemia
dc.subjectHLA
dc.subjectgenotyping
dc.subjecthomozygosity
dc.titleFrequency and relationship of HLA allele in Turkish patients with Fanconi anemia
dc.title.alternativeTürk Fanconi anemili hastalarda HLA alellerinin sıklığı ve ilişkisi
dc.typeArticle

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