Potential Applications of Photobiomodulation in Combinatorial Cancer Therapy: Developments in Diagnosis and Treatment

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dc.authoridEbru Nur Ay / 0000-0001-7121-4362
dc.authoridDuygu Hüsna Acar / 0009-0007-8782-7930
dc.authoridFerda Kaleağasıoğlu / 0000-0003-1511-0432
dc.authorscopusidFerda Kaleağasıoğlu / 6603420924
dc.authorwosidFerda Kaleağasıoğlu / E-9447-2011
dc.contributor.authorAy, Ebru Nur
dc.contributor.authorAcar, Duygu Hüsna
dc.contributor.authorKaleağasıoğlu, Ferda
dc.date.accessioned2025-04-18T09:10:45Z
dc.date.available2025-04-18T09:10:45Z
dc.date.issued25.11.2024
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractObjective: Over the last two decades, the potential applications of photobiomodulation therapy (PBMT) have garnered increasing attention. The mechanism of PBMT involves the absorption of light energy by cellular components, such as chromophores. This absorption initiates a cascade of biochemical reactions, including cellular signaling pathways, gene expression, and the production of various molecules such as reactive oxygen species, adenosine triphosphate, and growth factors. In this review, we aimed to investigate the potential applications of PBMT when combined with chemotherapy (CT), radiotherapy (RT), and immunotherapy. Material and Methods: PubMed (National Library of Medicine, ABD), Scopus (Elsevier, Hollanda), and Google Scholar (Google, ABD) were searched to obtain data. Results: Based on the results of in vitro and in vivo studies, PBMT acts as a chemo- and radio-sensitizer. It facilitates dose reduction and, notably, does not decrease but may increase the viability of noncancer cells. This property enables the protection of noncancerous cells against antineoplastic CT-related toxicity. The important factor in effectively employing PBMT for cancer treatment depends on selecting the correct dosage, including wavelength, power density, energy density, and exposure time. The accumulating evidence supporting the benefits of PBMT has led to its recommendation by the World Association for Laser Therapy for managing CT-related adverse effects. Conclusion: PBMT is a promising strategy for the combination therapy of cancer. Nevertheless, further studies are warranted to establish the precise protocols for PBMT. These studies are essential to address its limitations and uncover the benefits of light therapy that have not yet been fully explored.
dc.identifier.citationAY, E. N., ACAR, D. H., KALEAĞASIOĞLU, F. (2024). Potential Applications of Photobiomodulation in Combinatorial Cancer Therapy: Developments in Diagnosis and Treatment. Journal of oncological sciences , 10(1), 47 - 59. doi.org/10.37047/jos.2023-99295
dc.identifier.doi10.37047/jos.2023-99295
dc.identifier.endpage59
dc.identifier.issn2651-4532
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85188254855
dc.identifier.startpage47
dc.identifier.trdizinid1281506
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1281506/potential-applications-of-photobiomodulation-in-combinatorial-cancer-therapy-developments-in-diagnosis-and-treatment
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6710
dc.identifier.volume10
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAy, Ebru Nur
dc.institutionauthorAcar, Duygu Hüsna
dc.institutionauthorKaleağasıoğlu, Ferda
dc.institutionauthoridEbru Nur Ay / 0000-0001-7121-4362
dc.institutionauthoridDuygu Hüsna Acar / 0009-0007-8782-7930
dc.institutionauthoridFerda Kaleağasıoğlu / 0000-0003-1511-0432
dc.language.isoen
dc.publisherTürkiye Klinikleri Yayınevi
dc.relation.ispartofJournal of oncological sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLow level laser therapy
dc.subjectchemotherapy
dc.subjectimmunotherapy
dc.subjectradiotherapy
dc.titlePotential Applications of Photobiomodulation in Combinatorial Cancer Therapy: Developments in Diagnosis and Treatment
dc.typeArticle

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