A new Turkish pharmacokinetics software program for therapeutic drug monitoring of theophylline

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dc.authoridGülbeyaz Yıldız Türkyılmaz / 0000-0002-8601-0263
dc.authoridMehmet Ali Ege / 0000-0002-4953-2812
dc.authoridA. Levent Alparslan / 0000-0003-0113-6850
dc.authoridErcüment Karasulu / 0000-0002-3992-6201
dc.authoridLevent Kırılmaz / 0000-0003-2554-0823
dc.authorscopusidA. Levent Alparslan / 22133645600
dc.authorwosidA. Levent Alparslan / AAP-3253-2020
dc.contributor.authorTürkyılmaz, Gülbeyaz Yıldız
dc.contributor.authorEge, Mehmet Ali
dc.contributor.authorAlparslan, A. Levent
dc.contributor.authorKarasulu, Ercüment
dc.contributor.authorKırılmaz, Levent
dc.date.accessioned2025-04-18T06:29:53Z
dc.date.available2025-04-18T06:29:53Z
dc.date.issued28 Mart 2024
dc.departmentİstinye Üniversitesi, Diş Hekimliği Fakültesi, Klinik Bilimler Bölümü
dc.description.abstractIn this study, it was aimed to develop a Turkish software with pharmacokinetic (PK) data for therapeutic drug monitoring and IV dose adjustment of narrow therapeutic index theophylline. The study involved three groups, each comprising two rabbits The dose required for the target concentration (15µg/mL) was calculated with the developed program according to the weight of the rabbits in the first group. Blood samples taken at certain times were analyzed by validated HPLC method to calculate the elimination rate constant (ke) after IV bolus administration. The r2 values for ke were found to be 0.86 and 0.95. The second dose calculated according to revised PK findings was administered and blood samples were taken. When the analyzed results and theoretical results were compared, the deviation was found to be 5.53% and 8.795%. The findings were taken as the population PK for other applications. IV multiple dose bolus and IV fast-slow combined infusion were administered to the second group and the third group, respectively. The results obtained from the analysis of blood samples taken at the times determined according to the application were compared with the theoretical results. As a result, although there is a high difference between theory and practice at low concentrations, there is very little variation at high concentrations. By using this program, it has been achieved to keep theophylline at the desired level without reaching the minimum toxic concentration and without falling below the minimum effective concentration. It is thought that deviations will be reduced with larger samples.
dc.identifier.citationYıldız Türkyılmaz, G., Ege, M. A., Alparslan, A. L., Karasulu, E., vd. (2024). A new Turkish pharmacokinetics software program for therapeutic drug monitoring of theophylline. Erzincan University Journal of Science and Technology, 17(1), 113-128. https://doi.org/10.18185/erzifbed.1347386
dc.identifier.doi10.18185/erzifbed.1347386
dc.identifier.endpage128
dc.identifier.issue1
dc.identifier.startpage113
dc.identifier.trdizinid1231165
dc.identifier.urihttps://doi.org/10.18185/erzifbed.1347386
dc.identifier.urihttps://dergipark.org.tr/tr/pub/erzifbed/issue/83811/1347386
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6336
dc.identifier.volume17
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorAlparslan, A. Levent
dc.institutionauthoridA. Levent Alparslan / 0000-0003-0113-6850
dc.language.isoen
dc.publisherErzincan Binali Yıldırım Üniversitesi
dc.relation.ispartofErzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTDM
dc.subjecttheophylline
dc.subjectsoftware pharmacokinetic programme
dc.titleA new Turkish pharmacokinetics software program for therapeutic drug monitoring of theophylline
dc.title.alternativeTeofilinin terapötik ilaç izlemi için yeni bir Türkçe farmakokinetik yazılım programı
dc.typeArticle

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