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Öğe Biocompatible silver nanoparticles from apricot kernel skin: a green synthesis approach to antibacterial and antiangiogenic therapies(Springer Science and Business Media Deutschland GmbH, 2025) Nejati, Omid; Torkay, Gülşah; Girgin, Ayça; Zaman, Buse Tuğba; Akar, Remzi Okan; Giray, Betül; Ulukaya, EnginPlant-based AgNPs synthesis has recently gained popularity due to its cost-effectiveness, feasibility, and environmentally friendly nature. In this study, we utilized apricot kernel skin extract for the first time as both a green reducing agent for silver ions and a stabilizing agent for the resulting AgNPs solution. This solution exhibited remarkable stability and biological activity. The biosynthesized AgNPs were characterized using several spectroscopic approaches. Particle size and zeta potential were found to be 145.5 ± 62.02 nm and − 29.1 ± 5.68 mV, respectively. The dynamic light scattering findings revealed a low polydispersity index of 0.229, indicating that the monodispersity distribution in solution is mainly single-sized and uniform species. The TEM image indicated that the AgNPs were spherical. Even 3 months after synthesis, AgNPs were stable. The DPPH test demonstrated that AgNPs have moderate antioxidant activity. Furthermore, depending on the dose, it is found to have high antibacterial activity against different bacterial species. It was also discovered that AgNPs, which are highly biocompatible with red blood cells in terms of hemolysis activity assay, were more lethal to non-small cell metastatic lung cancer epithelial cells (H1299) than human lung bronchial epithelial cells (Beas2B) with an LC50 of 6.03 and 14.19 μg/mL, respectively, after 24 h treatment. At TGI concentration, AgNPs also significantly reduced H1299 cell migration. According to artificial intelligence analyses acquired from in ovo chorioallantoic membrane testing, AgNPs, which hold great potential for application in anticancer drug delivery systems, have been also found to reduce angiogenesis at low concentrations. © The Author(s), under exclusive licence to the Institute of Chemistry, Slovak Academy of Sciences 2024.Öğe Synthesis of calcium phosphate nanomaterial from quail eggshell for cadmium removal from wastewater and its genotoxic/cytotoxic properties(Springer Science and Business Media Deutschland GmbH, 2024) Demir, Cansu; Bakırdere, Bengisu Ece; Zaman, Buse Tuğba; Öner, Miray; Bozyiğit, Gamze Dalgıç; Ergenler, Ayşegül; Turan, Funda; Nejati, Omid; Öztürk, Ayça Bal; Çetin, Gülten; Bakırdere, SezginIn recent years, pollutants released into the environment from various sources threaten environmental health. Rapid industrialization and the constantly increasing needs of people facilitate the release of more hazardous wastes into the ecosystem. The presence of pollutants in water resources causes a wide range of adverse effects. In this study, calcium phosphate nanomaterial (Ca3(PO4)2 NM) was synthesized from biological waste eggshells for the cadmium removal in synthetic domestic wastewater, and a treatment method was developed using these NMs. The Ca3(PO4)2 NMs were produced by using a biowaste which provides the synthesis procedure greener approach. The biogenic NMs were used to remove toxic cadmium ions from wastewater samples. Cytotoxicity and genotoxicity studies of the synthesized NMs were also carried out, and their possible effects on the health of living organisms and the ecology were examined. In the developed method, the parameters affecting the removal of cadmium from wastewater samples were optimized and the removal efficiency was calculated by determining cadmium in a flame atomic absorption spectrophotometer system (FAAS). Synthetic domestic wastewater samples were utilized for evaluating the applicability of the developed treatment strategy. In addition, the adsorption capacity of the material for Cd2+ ion was calculated and the values obtained were modeled by using Langmuir adsorption isotherm (LAI). The calculated LAI parameters were within the appropriate limits, which proved that the developed NM can be used as an effective material for cadmium removal. Moreover, a new, rapid, and feasible synthesis strategy for the synthesis of Ca3(PO4)2 NM was presented in the literature. Graphical abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.Öğe Trace element determination using mass spectrometry coupled detection methods(Elsevier b.v., 2025) Chormey, Dotse Selali; Er, Elif Öztürk; Bodur, Sezin Erarpat; Zaman, Buse Tuğba; Bodur, Süleyman; Kustanto, Tülay Borahan; Kayın, İnci; Bakırdere, SezginAbout half a century ago, trace elements in the environment were restricted at upper parts per billion levels due to limited information on their toxicological effects on humans and other organisms in the environment. In this present day, stricter restrictions are being enforced by several regulatory authorities to curb the continuous release of trace elements into the environment through anthropogenic activities that have resulted from the demand to meet the global population increase. The severity of health disorders related to trace elemental exposure from different sources and doses seem to overshadow their relevance for several biological functions. Thus, toxicological studies that elucidate the harmful effects of chemicals and help regulators to set limits of restriction require very sensitive analytical instruments that offer selectivity and specificity for accurate and precise determinations. Mass spectrometry is a unique technique that suits the purpose of identifying, confirming and quantifying elements that emanate from various chemical species. Inductively coupled plasma mass spectrometry is a superior analytical technique used for the simultaneous determination of trace elements in various samples. This superior technique is further augmented by solid phase and liquid phase microextraction methods, which help separate trace elements from complex matrices into clean, readable and enriched forms for the instrument.Öğe Trace element determination using mass spectrometry coupled detection methods(Elsevier B.V., 2025) Chormey, Dotse Selali; Er, Elif Öztürk; Bodur, Sezin Erarpat; Zaman, Buse Tuğba; Bodur, Süleyman; Kustanto, Tülay Borahan; Kayın, İnci; Bakırdere, SezginAbout half a century ago, trace elements in the environment were restricted at upper parts per billion levels due to limited information on their toxicological effects on humans and other organisms in the environment. In this present day, stricter restrictions are being enforced by several regulatory authorities to curb the continuous release of trace elements into the environment through anthropogenic activities that have resulted from the demand to meet the global population increase. The severity of health disorders related to trace elemental exposure from different sources and doses seem to overshadow their relevance for several biological functions. Thus, toxicological studies that elucidate the harmful effects of chemicals and help regulators to set limits of restriction require very sensitive analytical instruments that offer selectivity and specificity for accurate and precise determinations. Mass spectrometry is a unique technique that suits the purpose of identifying, confirming and quantifying elements that emanate from various chemical species. Inductively coupled plasma mass spectrometry is a superior analytical technique used for the simultaneous determination of trace elements in various samples. This superior technique is further augmented by solid phase and liquid phase microextraction methods, which help separate trace elements from complex matrices into clean, readable and enriched forms for the instrument. © 2024 Elsevier B.V.
