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  • Küçük Resim
    Öğe
    Tamsulosin can improve lower urinary tract symptoms in patients under active surveillance due to low risk prostate cancer: prospective controlled study
    (Galenos Yayincilik, 2019) Dalkılıç, Ayhan; Bayar, Göksel; Kılınç, Muhammet Fatih; Yavuz, Abdulmecit; Tanrıverdi, Orhan; Horasanlı, Kaya
    Objective: We aimed to evaluate the efficacy of tamsulosin in the treatment of lower urinary tract symptoms (LUTS) in patients under active surveillance (AS) for low-risk prostate cancer (Pca). Materials and Methods: Patients who underwent prostate biopsy between 2010 and 2014 were evaluated prospectively. Inclusion criteria for AS were PSA level below 10 ng/mL, a tumor in a maximum of two cores, a tumor core percentage below 50%, a clinical stage <= T2a and a Gleason score <= 6. Patients under AS with LUTS were included in the study group and patients with benign pathology results with LUTS were included in the control group. International prostate symptom score (IPSS) and uroflowmetry test were used to evaluate LUTS. The maximum flow rate (Q(max)) was recorded. All patients received tamsulosin 0.4 mg once daily in a modified-release formulation (Flomax MR (R), Astellas, Japan). Transurethral resection prostatectomy (TUR-P) was performed when surgical treatment was necessary for obstruction despite tamsulosin treatment. Results: The study included a total of 91 patients, 41 patients in the AS group and 50 patients in the control group. Patients were assessed after six months. There was a 30% reduction in IPSS in the AS group and 24.5% in the control group (p=0.591). Q(max) increased by 20.4% in the AS group and by 20% in the control group (p=0.985). The need for TUR-P was similar between the two groups (14.6% vs 20%, p=0.503) during three-year follow-up. Conclusion: Tamsulosin can be used safely and with high efficacy for LUTS in patients under AS for low-risk Pca. The improvement in IPSS and Q(max), and the need for surgical treatment were similar to the control group.
  • Küçük Resim Yok
    Öğe
    The effects of microsurgical varicocelectomy performed for infertility on premature ejaculation
    (Springer science and business media b.v., 2024) Kızılkan, Yalçın; Duran, Mesut Berkan; Kayra, Mehmet Vehbi; Şahin, Bahadır; Yavuz, Abdulmecit
    Purpose To investigate the effects of varicocelectomy on premature ejaculation (PE) in patients with varicocele and infertility. Methods A total of 82 sexually active patients aged 18 years or over who had undergone microscopic subinguinal varicocelectomy with a clinical diagnosis of varicocele in 14 urology clinics between October 2021 and March 2023 with primary infertility were evaluated prospectively Patients were evaluated using the Turkish validated form of the 'Premature Ejaculation Diagnostic Tool' (PEDT) scale. A PEDT score of 11 or above was taken to indicate the presence of PE. Turkish validated forms of PEDT and International Index of Erectile Function-5 (IIEF-5) were completed in all patients pre-operatively and at 3 and 6 months post-operatively. Intravaginal ejaculatory latency time (IELT) and serum testosterone measurements were also recorded. Results Left varicocelectomy was performed in 70.7% and bilateral varicocelectomy in 29.3% of the participants. A significant difference was found between pre- and post-operative PEDT scores (x 2 (2) = 130.1, p < 0.001). A significant difference was observed between pre- and post-operative IELT time (x 2 (2) = 143.2, p < 0.001). IIEF-5 scores differed before and after surgery (x 2 (2) = 59.5, p < 0.001). A difference was found between the testosterone levels measured before and after surgery (x 2 (2) = 40.9, p < 0.001). No statistically significant difference was observed between the third- and sixth-month testosterone values (p = 0.183). Testosterone levels (p = 0.001) and IELT scores (p < 0.001) were significantly higher, while PEDT scores (p < 0.001) were significantly lower in the bilateral varicocelectomy group at the sixth post-operative month. Conclusion In light of our findings, it is recommended that infertile patients with varicocele be informed of the positive effects of varicocelectomy on PE.