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    Antibacterial, antioxidant, and healing potential of wound dressings utilizing cranberry extract in combination with methacrylated polyvinyl alcohol and methacrylated sericin
    (Springer, 2024) Özkahraman, Bengi; Torkay, Gülşah; İdil, Neslihan; Özbaş, Zehra; Bal Öztürk, Ayça
    PurposeHydrogels, due to their hydrophilic nature and tunable properties, have emerged as promising materials for wound dressings. Notably, the ability to incorporate antibacterial and antioxidant agents into hydrogels offers significant advantages in reducing bacterial colonization, scavenging reactive oxygen species (ROS), mitigating inflammation, and accelerating wound closure. This study investigated the potential of cranberry extract (CR)-incorporated poly(vinyl alcohol)/silk sericin (PVAMA/SERMA) hydrogel wound dressings to promote effective antimicrobial activity and wound healing.MethodsMethacrylated poly(vinyl alcohol) (PVAMA) and silk sericin (SERMA) pre-polymers were synthesized. The wound dressings consisting of PVAMA, SERMA, and CR were fabricated by photopolymerization method. The chemical and thermal structures of wound dressings were investigated by FTIR and TGA analysis. The assessment of the physical characteristics was conducted through the analysis of swelling and in vitro degradation tests. The effect of various concentrations of CR in wound dressings on cytotoxicity and healing performance of NIH/3T3 fibroblast cell line was examined using extract-based MTT and scratch assays, respectively. Antibacterial and antioxidant properties of the wound dressing were performed against Escherichia coli and Staphylococcus aureus aureus using the agar diffusion method and DPPH assay, respectively.ResultsThe findings suggest that CR-loaded PVAMA/SERMA hydrogels hold promise as novel wound dressing materials due to their enhanced antibacterial, antioxidant, and wound healing capabilities, potentially accelerating wound recovery.Lay SummaryHydrogels, due to their hydrophilic nature, tunable chemical, mechanical, and biological properties, have shown great promises for wound dressing application. Notably, antibacterial and antioxidant hydrogels reduce bacterial colonization and infection, scavenge ROS, relieve inflammation, and accelerate wound healing. In this study, The PVAMA/SERMA-based wound dressings with various concentrations of CR (0, 1, and 2 wt % of polymer) were prepared by the photopolymerization method to achieve effective antimicrobial and wound healing potential.
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    Artificial Intelligence in Cancer: A SWOT Analysis
    (İzmir Academy Association, 31 Aralık 2024) Torkay, Gülşah; Fadlallah, Nouran; Karagöz, Ahmet; Canlı, Mesut; Saydam, Ezgi; Mete, Ayşenur; Kızılışık, Furkan; Darici, Hakan; Yeşil, Yusuf
    Cancer, a collection of maladies that has undergone extensive examination over centuries, remains a formidable challenge. Despite the array of available pharmacological and therapeutic interventions, the intricate molecular dynamics and heterogeneity of cancer continue to challenge the scientific community. Artificial Intelligence (AI) emerges as a promising avenue, offering the potential for expedited, precise diagnostics devoid of human expertise. Additionally, AI facilitates the tailoring of patient-specific therapeutic strategies targeting various facets of cancer, spanning macroscopic to microscopic levels. Nonetheless, it is imperative to scrutinize the potential benefits and limitations of AI technologies in this context. This review undertakes a comprehensive Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis of AI's application in cancer. An extensive compilation of AI applications encompasses predictive modeling, diagnostic capabilities, prognostic assessments, and personalized therapeutic modalities, spanning genomic analyses to individualized treatment regimens. The synthesis of evidence suggests that the advantages of AI outweigh its drawbacks; nevertheless, obstacles to its widespread integration persist.
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    The effect of thiol functional groups on bovine serum albumin/chitosan buccal mucoadhesive patches
    (Editions de Sante, 2022) Bal Öztürk, Ayça; Alarçin, Emine; Özbaş, Zehra; Özkahraman, Bengi; Torkay, Gülşah
    In this research, the effect of thiol functional groups on bovine serum albumin (BSA)/chitosan (Chi) based buccal mucoadhesive patch was investigated. Thiolated BSA (BSA-SH) was prepared via 2-mercaptoethanol. FTIR and 1H NMR results confirmed that BSA-SH was synthesized successfully. The buccal mucoadhesive patches were fabricated by the solvent casting method. Following the structural characterization of BSA/Chi and BSA-SH/Chi buccal patches, the mechanical characterization was performed by tensile tests. The drug release from triam- cinolone acetonide (TR) loaded buccal patches was evaluated in-vitro in simulated salivary. According to the ex- vivo buccal adhesion experiments, the mechanical and mucoadhesion properties of BSA-SH/Chi buccal patch had improved compared to BSA/Chi buccal patch. The total cumulative TR permeated after 12 h was higher for BSA- SH/Chi than BSA/Chi buccal patches. The developed mucoadhesive buccal patches were found to be biocom- patible in vitro. To conclude, the thiolated BSA-SH/Chi buccal adhesive patch is a promising biomaterial for a satisfied drug delivery, which provides advantages for various oral applications.
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    The effect of vitamin c in the formulation of pectin/thiolated alginate buccal adhesive patches: in vitro and ex vivo evaluation
    (Elsevier Ltd., 2022) Özkahraman, Bengi; Torkay, Gülşah; Özbaş, Zehra; Bal Öztürk, Ayça
    The present study outlines the prospect of a pectin (Pec)/modified alginate (Alg) buccal patch as drug delivery device in the localized treatment of oral cavity diseases. Firstly, Alg was modified with acrylic acid, and thiolated with cystein to enhance its mucoadhesive properties. Then modified Alg was characterized with Fourier transform infrared (FTIR) and proton nuclear magnetic resonance (1HNMR) spectroscopy. As a proof of concept, Pec/modified Alg buccal patches were formed via the conventional solvent casting technique. Then the patches were characterized by FTIR and differential scanning calorimetry/thermal gravimetric analysis (DSC/TGA). Vitamin C (Vit C) was used for in vitro drug release assay, and the release amount was 2.10 mg/g polymer in simulated salivary pH 6.8. Ex vivo mucoadhesion assays of Vit C loaded Pec/modified Alg patch did not have a negative effect on the mucoadhesion feature of the material. The cytotoxicity study indicated that Pec/modified Alg buccal patches did not exhibit apparent cytotoxicity against NIH/3T3 cell lines. Notably, it was found that Vit C in the patch formulation has an accelerating effect on wound healing. According to all results, Vit C loaded Pec/modified Alg buccal patch might be a promising candidate for localized buccal drug release systems.
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    Preparation of quercetin incorporated photocrosslinkable methacrylated gelatin/methacrylated kappa-carrageenan antioxidant hydrogel wound dressings
    (SPRINGER INT PUBL AG, 2022) Özbaş, Zehra; Torkay, Gülşah; Bal Öztürk, Ayça; Özkahraman, Bengi
    Wound dressings with antioxidant potential have attracted remarkable concerns for wound healing. The purpose of this work is to investigate blank, and quercetin loaded photocrosslinkable methacrylated gelatin (GelMA)/methacrylated kappa-carrageenan (KapMA) hydrogel. Wound dressings were produced by the photocrosslinking method in the presence of a photoinitiator. Quercetin was incorporated in photocrosslinkable GelMA/KapMA wound dressings with different ratios. Besides, Fourier Transform Infrared Spectroscopy, thermal gravimetric analysis, swelling, and degradation tests were performed for characterization studies of the hydrogel wound dressings. The release of quercetin from GelMA/KapMA wound dressings was investigated at a physiological pH value of 7.4 at 37 degrees C. The antioxidant activity of the hydrogel dressings was further evaluated by 2,2-diphenyl-1-picrylhydrazyl method. Biocompatibility of wound dressings was assessed using MTT assay tests on NIH-3T3 cell line, which evaluated its suitability in biomaterial applications. The obtained results indicated that quercetin incorporated photocrosslinked GelMA/KapMA wound dressings provide antioxidant activity, and they could be the ability for the potential wound dressings applications.