Yazar "Salehi, Saeideh" seçeneğine göre listele
Listeleniyor 1 - 3 / 3
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Amine-functionalized mesoporous silica nanoparticles decorated by silver nanoparticles for delivery of doxorubicin in breast and cervical cancer cells(Elsevier, 2024) Ghobadi, Melika; Salehi, Saeideh; Ardestani, Mohammad Taha Salmanifard; Mousavi-Khattat, Mohammad; Shakeran, Zahra; Khosravi, Arezoo; Cordani, Marco; Zarrabi, AliNanocarriers have demonstrated promising potential in the delivery of various anticancer drugs and in improving the efficiency of the treatment. In this study, silver nanoparticles (AgNPs) were green-synthesized using the extracts of different parts of the pomegranate plant, including the peel, flower petals, and calyx. To obtain the most efficient extract used for the green synthesis of AgNPs, all three types of synthesized nanoparticles were characterized. Then, (3-Aminopropyl) triethoxysilane-functionalized mesoporous silica nanoparticles (MSNs-APTES) decorated with AgNPs were fabricated via a one-pot green-synthesis method. AgNPs were directly coated on the surface of MSNs-APTES by adding pomegranate extract enriched with a source of reducing agent leading to converting the silver ion to AgNPs. The MSN-APTES-AgNPs (MSNs-AgNPs) have been thoroughly characterized using nanoparticle characterization techniques. In addition, DNA cleavage and hemolysis activities of the synthesized nanoparticles were analyzed, confirming the biocompatibility of synthesized nanoparticles. The Doxorubicin (DOX, as a breast/cervical anti-cancer drug) loading (42.8%) and release profiles were investigated via UV-visible spectroscopy. The fibroblast, breast cancer, and cervical cancer cells' viability against DOX-loaded nanoparticles were also studied. The results of this high drug loading, uniform shape, and small functionalized nanoparticles demonstrated its great potential for breast and cervical cancer management.Öğe Exploring the evolution of tissue engineering strategies over the past decade: From cell-based strategies to gene-activated matrix(Elsevier, 2023) Esmaeili, Yasaman; Bidram, Elham; Bigham, Ashkan; Atari, Mehdi; Azadani, Reyhaneh Nasr; Tavakoli, Mohamadreza; Salehi, SaeidehThe advancement of tissue engineering for regenerating injured tissues and organs has progressed significantly in recent years. Various techniques have been used to modify the cells' microenvironments in the targeted tissue via their extracellular environment for achieving these aims. The 3D structured scaffolds alone or combined with bioactive molecules or genes and cells hold great promise for the development of functional engineered tissues. As an emerging and state-of-the-art technology in this field, integrating tissue engineering and gene therapy, known as gene-activated matrix (GAM), has gained immense attention as a promising approach for restoring damaged or dysfunctional tissues' function and structure. Nonetheless, fabricating GAMs with low cytotoxicity, high transfection efficiency, and long-term gene delivery efficiency is still challenging. Here we provide a complete overview of different tissue engineering approaches and their ongoing preclinical research trials. Moreover, the GAM strategy with a focus on gene-activated matrix development, faithful application, and future prospects as a tissue repair and regeneration replacement is assayed. The challenges and future research prospects in regenerative medicine are also presented. Eventually, we propose that GAMs offer a basic mechanistic infrastructure for tissue engineering to pave the way for clinical translation and achieve personalized regenerative medicine.Öğe Exploring the evolution of tissue engineering strategies over the past decade: From cell-based strategies to gene-activated matrix (vol 81, pg 137, 2023)(Elsevier, 2023) Esmaeili, Yasaman; Bidram, Elham; Bigham, Ashkan; Atari, Mehdi; Azadani, Reyhaneh Nasr; Tavakoli, Mohamadreza; Salehi, Saeideh[Abstract Not Available]
