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Öğe Alpha-lipoic acid intoxication in an adolescent girl(2021) D. Al-Mendalawi, Mahmood; Polat, Sinem; Kılıcaslan, Onder; Turan Sonmez, FeruzaDear Editor, Polat et al. (1) described nicely the clinical picture, management plan, and favorable outcome of a case of alpha-lipoic acid (ALA) intoxication in a 16-year-old Turkish girl. On the basis of her medical history, Polat et al. (1) mentioned that the patient took three pills, each of 600 mg ALA, approximately 2 hours before hospital admission to self-treat her headache with intervals of half an hour. I assume that the claimed self-treatment should not mask the potential suicidal attempt in the studied patient. Worldwide, suicide and suicide attempts are important health risks among adolescents with grave consequences (2). In an interesting Turkish study involving medico-legal autopsy cases, childhood and adolescent (aged 0-18 years) deaths constituted 24.4% of all cases. Suicide was the origin of death in 13.4% of cases recruiting victims aged <18 years. Females comprised the majority of the suicide cases (62.9%), and adolescents aged 16-18 years constituted the overwhelming majority (70.4%) of all childhood suicides. The mean age was 16.13 years. The most frequent method of suicide in females was poisoning (3). An in-depth psychological assessment of the studied patient would have solicited. If that assessment was to unveil potential suicide thought and intention, strict actions must be geared to prevent further incidents. Although the studied patient favorably survived that incident, fatal suicidal intoxication with ALA has been reported in a 14-year-old German girl (4)Öğe Alpha-lipoic acid intoxication in an adolescent girl: case report and review of the literature(Kare Publishing, 2020) Polat, Sinem; Kılıcaslan, Onder; Sonmez, Feruza TuranAlpha-lipoic acid is a widely used medication that does not need a pre-scription. Although it is safely used in adults, hitherto no safe dose for children has been reported, and there is no known antidote. The med-ical literature provides four reports of alpha-lipoic acid intoxication in the pediatric population to date. This case-report is the lowest known dose of alpha-lipoic acid intake leading to poisoning in a teenager.Öğe Alpha-lipoic acid intoxication in an adolescent girl:case report and review of the literature(2022) Polat, Sinem; Sönmez, Feruze Turan; Kılıçaslan, ÖnderAlpha-lipoic acid is a widely used medication that does not need a prescription. Although it is safely used in adults, hitherto no safe dose for children has been reported, and there is no known antidote. The medical literature provides four reports of alpha-lipoic acid intoxication in the pediatric population to date. This case-report is the lowest known dose of alpha-lipoic acid intake leading to poisoning in a teenager.Öğe Alpha-lipoic acid intoxication in an adolescent girl:Case report and review of the literature(Alpay Azap, 2020) Polat, Sinem; Kılıçaslan, Önder; Sönmez, Feruza TuranAlpha-lipoic acid is a widely used medication that does not need a prescription. Although it is safely used in adults, hitherto no safe dose for children has been reported, and there is no known antidote. The medical literature provides four reports of alpha-lipoic acid intoxication in the pediatric population to date. This case-report is the lowest known dose of alpha-lipoic acid intake leading to poisoning in a teenager.Öğe Evaluation of forensic cases in the pediatric intensive care unit(KARE PUBL, 2021) Polat, Sinem; Terece, Cem; Yaman, Ayhan; Gürpınar, KağanObjectives: Traffic accidents, falls, assaults, occupational accidents, intoxications, burns, electric shock, lightning strike, all cases of asphyxia, penetrating and firearm injuries, suspected or definite cases of sexual abuse, and suicide attempts should be evaluated in the forensic category. In this study, we aimed to present our intensive care experiences in forensic cases. Methods: We retrospectively evaluated forensic cases admitted to our Pediatric Intensive Care Unit between 1 February 2017 and 1 September 2018. Results: This study included 153 children, 65 (42.5%) boys and 88 (57.5%) girls. The forensic causes of hospitalizations in the intensive care unit included drug intoxication with a rate of 54.9%, followed by suicide attempts with 24.2%, falling from a high place with 5.2%, child abuse with 5.2%, pedestrian (out-of-vehicle) traffic accidents with 2.6%, drowning in water with 2.6%, road (in-vehicle) traffic accidents with 2%, electric shocks with 2%, and CO (carbon monoxide) poisoning with 1.3%. The drug intoxication was caused by drugs prescribed to the mother and the child with a rate of 40.6% and 27.1%, respectively. Analgesic anti-inflammatory drugs (33.1%) and antidepressant drugs (22.3%) were identified as major causes of intoxication. In addition, paracetamol was the most common cause of intoxication, with a rate of 21.9% among all intoxication cases and 72.5% in the analgesic group. Amitriptyline was the most common agent in the antidepressant group (59.2%). The admission rate to the intensive care unit between 08:00 and 14:00 was 35.1% for suicide attempts and 16.4% for non-suicide attempts, with a statistically significant difference (p=0.025; p<0.05, respectively). Conclusion: Drug intoxications had the highest rate of forensic cases followed in our pediatric intensive care unit. The majority of these intoxications (69.4%) arose from accidental drug ingestion. Therefore, we believe that there may be a significant decrease in the number of hospitalizations of forensic cases associated with drug intoxications in pediatric intensive care units by preventing children's access to drugs.Öğe Infant death due to aluminum phosphide intoxication, an uncontrolled insecticide used : case report(DergiPark, 2019) Terece, Cem; Sagukpinar, Veysel Osman; Ozdemir, Nazim; Polat, SinemPhosphine gas is a gas that is frequently used as rodenticide and insecticide due to its high diffusion capacity and the absence of residues in agricultural products. Since this gas is highly toxic, it is found in our country as aluminum phosphite tablets impregnated with clay, these tablets emit phosphine gas when they meet with the moisture in the air or gastric hydrochloric acid. Mortality rates in aluminum phosphite intoxications are 40-80% depending on the exposure dose. There is no control mechanism in the supply of aluminum phosphide tablets which are so dangerous and no information is given about the serious conditions that may occur during the use of these tablets. A 2 month old baby, whose family practiced drying pepper-eggplant, was reported to have been exposed to phosphine gas by inhalation, admitted to hospital with vomiting and cyanosis and lost his life within 24 hours. We present our case, who lost his life due to erroneous usage of aluminum phosphite, with additional emphasis on early diagnosis, treatment and gathering sample for toxicologic analysis, with corresponding forensic and medical documents.Öğe Re: Alpha-lipoic acid intoxication in an adolescent girl(AVES, 2021) Polat, Sinem; Kilicaslan, Onder; Sonmez, Feruza TuranDear Editor, First of all, we would like to thank our esteemed colleague for his/her criticism and for providing the opportunity to illuminate the point we did not emphasize in our article.
