DSpace Arşivi :: by Yazar "Kuruca, Serap Erdem" değerine göre listeleniyor

Listeleniyor 1 - 1 / 1

Silver nanoparticle/capecitabine for breast cancer cell treatment
(Pergamon-Elsevier Science Ltd, 2019) Hepokur, Ceylan; Kariper, İshak Afşin; Mısır, Sema; Ay, Ebru Nur; Tunoğlu, Servet; Ersez, Mediha Süleymanoğlu; Zeybek, Ümit; Kuruca, Serap Erdem; Yaylım, İlhan
This study aimed to evaluate antiproliferative and proapoptotic effects of Capecitabine bonded silver particles on human breast cancer cells (MCF-7). Different sizes of Ag NPs (in sizes 5, 10, 15, 30 nm) were synthesized. The characterization of silver and drug-bonded silver nanoparticles was performed through UV-VIS, FTIR, and SEM analysis. Silver and drug-bonded silver nanoparticles were measured by zetasizer. Antiproliferative and proapoptotic effects of capecitabine, silver and drug-bonded silver nanoparticles were evaluated using XTT, Anneksin V, respectively. According to the results, silver nanoparticles of 10 nm size have shown the lowest toxic effect. Drug-bonded nanoparticles significantly increased the number of early and late apoptotic cells on MCF-7 cells.