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    Evaluating the utility of the AF Genital System test for pathogen diagnosis in acute male urethritis
    (WILEY, 2022) Sarıer, Mehmet; Sepin, Nevgun; Emek, Mestan; Germen, Aysegul Tezcan; Hoscan, Mustafa Burak; Konuk, Elcin; Turgut, Hasan
    This study evaluated the effectiveness of the A.F. Genital System (Liofilchem®, Italy) in detecting pathogens compared with multiplex real- time polymerase chain reaction (PCR) in men with acute urethritis. Men diagnosed as having acute urethritis between 1 April 2021 and 31 December 2021 were included. Urethral swab samples were ob-tained for A.F. Genital System and PCR testing in a randomly determined order. The efficacy of the A.F. Genital System was analysed by comparing the results of the two tests. The study included 83 patients (mean age 34.1 ± 11.3 years). A urethritis patho-gen was detected in 69 patients (83.1%) by PCR and only 15 patients (18.1%) with the A.F. Genital System. The sensitivity of the A.F. Genital System in detecting acute urethritis pathogens was 21.7% (95% confidence interval [CI]: 13.6– 32.8), and the specificity was 100% (95% CI: 78.5– 100). Its sensitivity was 20% (95% CI: 7.1– 45.2) in the diagnosis of gonococcal urethritis and 19.1% (95% CI: 11.2– 30.4) in the diagnosis of non- gonococcal urethritis. PCR detected two or more urethritis pathogens in 9 patients (13.0%), while no polymicrobial infection was detected with the A.F. Genital System. Based on the results of multiplex real- time PCR, the A.F. Genital System had very low sensitivity in the detection of pathogens in acute male urethritis. It should be kept in mind that using this test in patients with acute urethritis may result in a high missed diagnosis rate for urethritis pathogens.
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    Evaluation of histopathologic results of testicular tumors in Antalya: multi center study
    (Galenos Yayincilik, 2020) Sarıer, Mehmet; Tunc, Mustafa; Ozel, Esin; Duman, Ibrahim; Kaya, Sagfettin; Hoscan, Mustafa Burak; Unsal, Cagatay
    Objective: Testicular tumors constitute 1% of all malignancies in men. Being a relatively uncommon tumor, there are few descriptive studies in the literature. The aim of this study is to retrospectively investigate the histopathological results of testicular tumors in our region. Materials and Methods: In this descriptive multicenter study, we evaluated the histopathologic results of 124 patients who underwent radical or partial orchiectomy with a diagnosis of testicular tumor between 2011 and 2019 in the region of Antalya, Turkey. All specimens were examined by the pathologists in a single center. Data pertaining to patient age, type of operation, histopathological tumor type, tumor size, and pathological stage of the primary tumor (pT) were analyzed. Results: The mean age of the 124 patients included in the study was 35.14 +/- 15.3 (2-80) years. Most (98.4%) of the analyzed specimens were radical orchiectomy materials, while only 1.6% were partial orchiectomy materials. Mean tumor size was 4.01 +/- 2.29 (0.5-11) cm. Tumor size was <= 2 cm in 29 (23.4%) specimens and >= 2 cm in 95 (76.6%) specimens. In terms of histopathology, 76.8% were germ cell tumors, 6.4% were gender cord-stromal tumors, 4.8% were ductal canal and rete testis tumors, and 12% were secondary tumors of the testis. Pathological stage of the pT was pT1 in 46%, pT2 in 39%, and pT3 in 15% of the patients. Conclusion: Although patient age and histopathological distribution of testicular tumors were generally consistent with the literature, the average tumor size in the orchiectomy materials was notably large. Initiatives are required to increase public awareness of the importance of early detection. In addition, our findings suggest that urologists feel hesitant to practice testis-sparing surgery despite recommendations in international guidelines.