Yazar "Heydari, Parisa" seçeneğine göre listele

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    Alginate-based nanocomposite incorporating chitosan nanoparticles: A dual-drug delivery system for infection control and wound regeneration
    (Editions de sante, 2025) Mousavi, Seyed Javad; Heydari, Parisa; Javaherchi, Pouya; Kharazi, Anoushe Zargar; Zarrabi, Ali
    In this study, a hydrogel-based nanocomposite was fabricated as a novel wound dressing and drug delivery system. Initially, insulin-loaded chitosan nanoparticles (CSNP-INS) were produced using the ionic gelation technique. Subsequently, the CSNP-INS were introduced into ciprofloxacin-loaded sodium alginate (SA-Cip) hydrogel at two different concentrations (0.5 % and 1 % w/v), followed by crosslinking with CaCl2 after freezedrying to enhance its physical and biological properties. The CSNP-INS nanoparticles had an average size of 173.6 f 1.76 nm and effectively encapsulated 70 % of the INS. Physicochemical characterization revealed that SA-Cip/1%CSNP-INS has significant swelling (2996 f 31.55 %) and high hydrophilicity (16.94 f 0.99 degrees), along with slow degradation due to the electrostatic interaction between CSNP and SA hydrogel (80 % weight loss after 14 days). Moreover, the mechanical properties were enhanced due to the higher concentration of CSNP (83 f 1.9 kPa), with a Young's modulus of 83 f 1.9 kPa. The release profile of INS after incorporation of CSNP-INS into the hydrogel was slower and more sustained. On the other hand, Cip showed a burst release (100 % within 6 h). In vitro assays of the fabricated hydrogels on fibroblastic cells demonstrated high cell viability, enhanced cell migration, and complete in-vitro wound closure (100 % within 24 h). Further analysis of the inflammatory response of hydrogels revealed a significant impact on modulating inflammation markers including a decrease in TNF-alpha and an increase in TGF-beta. Cip and INS facilitate different wound-healing stages, ensuring efficient and accelerated wound healing. This study underscores the potential of the developed hydrogel as groundbreaking wound dressing, offering enhanced wound healing capabilities through an innovative mechanism of controlled and sustained drug release.
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    Carboxymethyl cellulose/sodium alginate hydrogel with anti-inflammatory capabilities for accelerated wound healing; In vitro and in vivo study
    (Elsevier, 2024) Hosseini, Seyed Mohammad Reza; Heydari, Parisa; Namnabat, Mahtab; Azadani, Reyhaneh Nasr; Gharibdousti, Fateme Azimi; Rizi, Elmira Mousavi; Khosravi, Arezoo; Zarepour, Atefeh; Zarrabi, Ali
    Recently, managing the chronic skin wounds has become increasingly challenging for healthcare professionals due to the intricate orchestration of cellular and molecular processes involved that lead to the uncontrollable inflammatory reactions which hinder the healing process. Therefore, different types of wound dressings with immunomodulatory properties have been developed in recent years to effectively regulate the immune responses, enhance angiogenesis, promote re-epithelialization, and accelerate the wound healing process. This study aims to develop a new type of immunomodulatory wound dressing utilizing carboxymethyl cellulose (CMC)/sodium alginate (Alg)-simvastatin (SIM) to simultaneously enhance the inflammatory responses and the wound healing ratio. The CMC/Alg-SIM hydrogels exhibited appropriate swelling ratio, water vapor transmission rate, and desirable degradation rate, depending on the SIM content. The fabricated dressing showed sustained release of SIM (during 5 days) that improved the proliferation of skin cells. According to the in vitro findings, the CMC/Alg-SIM hydrogel exhibited controlled pro-inflammatory responses (decreased 2.5- and 1.6-times IL-6 and TNF-alpha, respectively) and improved secretion of anti-inflammatory cytokines (increased 1.5- and 1.3-times IL-10 and TGF-beta, respectively) in comparison with CMC/Alg. Furthermore, the CMC/Alg-SIM hydrogel facilitated rapid wound healing in the rat model with a full-thickness skin defect. After 14 days post-surgery, the wound healing ratio in the CMC/Alg hydrogel group (-93%) was significantly greater than the control group (-58%). Therefore, the engineered CMC/Alg-SIM hydrogel with desired immunomodulatory properties possesses the potential to enhance and accelerate skin regeneration for the management of chronic wound healing.
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    Sustained release investigation of curcumin and ciprofloxacin on coaxial electrospun nanocomposite scaffold of poly (3-hydroxybutyrate)-poly glycerol sebacate: an approach for skin regeneration
    (Springer nature, 2025) Hosseini, Seyed Mohammad Reza; Heydari, Parisa; Azadani, Reyhaneh Nasr; Iravani, Siavash; Zarrabi, Ali
    The utilization of biomaterial scaffolds may promote the regeneration of cutaneous wounds. The investigation focused on fabricating an innovative type of scaffold for skin tissue regeneration through the coaxial electrospinning technique. The scaffold consisted of two segments: the core layer accommodated a combination of polyglycerol sebacate (PGS) and curcumin (Cur), while the shell layer contained poly(3-hydroxybutyrate) (PHB) and ciprofloxacin (CIP). An evaluation was conducted on the physical and mechanical properties, drug release characteristics, and cellular responses of the scaffolds. The assessment revealed that the fiber diameters and porosity of PGS/PHB and PGS/PHB-Cur/CIP were measured at 400-480 nm and 83-86%, respectively. The transmission electron microscopy (TEM) findings exhibited distinct core and shell structures in the PGS/PHB-Cur/CIP specimens. The specific aspects of the PGS/PHB-Cur/CIP scaffold, such as its controlled degradation (below 50% over 21 days), sustained drug release behavior of Cur and CIP (over 5 days), and optimal strength attributes (stress strength similar to 0.104 MPa), differentiate it from traditional wound coverings. Specifically, the incorporation of CIP and Cur into the fiber configuration enhanced the viability and adhesion of cells, resulting in an appropriate morphology. Therefore, the coaxial PGS/PHB-Cur/CIP demonstrates a heightened potential for wound dressing application or as a skin substitute.