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Assessment of Centella Asiatica Extract Containing Dual-crosslinked Gel-MA/Pec Hydrogels as Wound Dressing
(2022) Aklar, Demet Akalgan; Albayrak, Betül; Gelal, Melisa; İzbudak, Burçin; Özkahraman, Bengi; Öztürk, Ayça Bal
In the present work, 3D-printed wound dressings containing different amounts of Centella Asiatica (CA) extract were synthesized via dual-crosslinking method. Methacrylic anhydride modified gelatin (Gel-MA) and pectin (Pec) were chosen as the base material for dressings. A dual crosslinked network was formed with Gel-MA photo-crosslinking using Irgacure 2959 and Pectin (Pec) psychical-crosslinking using Ca++ ions. Meanwhile, the developed dual-crosslinked hydrogel dressings were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, and mechanical, swelling, in vitro degradation as well as ex vivo bioadhesion tests. As the amount of CA in the dressing hydrogels increased, the degradation rates increased. In addition, the prepared dressings provide good bioadhesion on the chicken skin. Moreover, (3-(4,5-Dimethylthiazol- 2-yl)-2,5-Diphenyltetrazolium Bromide) (MTT) assay revealed cell viability of Gel-MA/ Pec hydrogel dressings containing CA extract. The results presented the dressings as a promising biomaterial to be used for wound healing purposes, which should be further investigated in future.