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    Haplotypes rich in activating killer-cell immnuglobulin-like receptor genes are associated with delay on age of myeloma onset
    (CIG MEDIA GROUP, 2021) Akın, Hasan Yalım; Seval, Güldane Cengiz; Atilla, Pınar Ataca; Yurdakul Mesutoğlu, Pınar; Otlu, Taner; Anlıaçık, Rıdvan; Dalva, Klara; Gürman, Günhan; Beksaç, Meral
    Natural killer (NK) cells are known for their anti-tumoral cytotoxic effects. Effector NK-cell functions are controlled by interactions between inhibitory and activating killer-cell immnuglobulin-like receptors (iKIRs and aKIRs) on NK cells in the presence of human leukocyte antigen (HLA) class I ligands on target cells. The aim of this study was to investigate the frequency of KIR genotypes with/without their cognate ligands among myeloma (MM) patients compared to a healthy population.