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    Developing multifunctional pectin-based hydrogel for wound dressing: In silico, in vitro and in vivo evaluation
    (Pergamon-elsevier science, 2024) Kocaağa, Banu; Öztürk, Yetkin; Kurçin, H. Ceren; Güner-Yılmaz, Ö. Zeynep; Kürkcüoğlu, Özge; Tatlıer, Melkon; Özdemir, İlkay; Demirci, Elif Kervancıoğlu; Kotil, Tuğba; Solakoğlu, Seyhun; Aksu, Burak; Batirel, Saime; Bal-Öztürk, Ayça; Güner, F. Seniha
    Multifunctional hydrogel wound dressing with high hemostatic, antioxidant, and self-healing activity is desirable in clinical applications. In this contribution, we developed two distinct hydrogel formulations, namely PZ and PTBA, by employing low methoxyl pectin (P), zeolite, or 2-thiobarbituric acid (TBA) for sustained release of procaine (PC) in a controlled manner up to 40 h. These hydrogel systems (PZ and PTBA) utilize dynamic reversible hydrogen bonds between the components and a metal coordination bond between carboxyl acid groups of pectin chains and Ca2+ to confer self-healing properties, as demonstrated by molecular dynamics (MD) and rheological analyses. Moreover, PZ and PTBA hydrogels possess superior antioxidant, hemostasis, biocompatibility, and antibacterial activities. The data from the mouse skin incision model and infected full-thickness skin wound model demonstrated the highest wound closure rate (wound closure area per day) was achieved by the PZ (4.72) and PTBA (4.62) groups on day 21, which was better than the control (4.2) and Kaltostat groups (4.05) (p < 0.05). PZ and PTBA's effectiveness in wound closure and acceleration of the wound healing process, highlighting its significant potential in wound management.
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    Enhancing the adhesiveness capacity of tissue adhesives: exploring the impact of silk fibroin concentration and curing time on the efficacy of corneal adhesives
    (Elsevier ltd, 2025) Tanrıverdi, Ayşegül; İzbudak, Burçin; Dastjerd, Samin; Zamani, Elaleh; Bal-Öztürk, Ayça
    The current study delved into developing biocompatible silk fibroin (SF) hydrogel-based adhesives and assessed the effect of various concentrations of SF and the visible light exposure duration during the riboflavin-mediated photo-crosslinking process to promote the in vitro/ex vivo performance of them as an ocular tissue adhesive. To accomplish this purpose, the SF solution with high adhesion features that was extracted from silk cocoons underwent exposure for durations of 1, 2, and 4 min, with varying SF concentrations (7.5 %, 15 %, and 22.5 % w/ v). The physicochemical properties of the SF adhesives, such as mechanical strength and biological adhesion behaviors, were enhanced by the increase in SF contents and irradiation time that were investigated by the characterizations of the adhesives using various techniques, which was attributed to the high density of dityrosine and beta-sheet crosslinking agents in the adhesive network. Furthermore, the interaction between tyrosine residues in SF and ocular aqueous humor led to the formation of covalent di-tyrosine crosslinking, which improved the performance of the developed corneal adhesives. SF adhesives exhibited nontoxicity behaviors towards human corneal fibroblast cell lines (HCFs), and findings of DAPI/Actin and PrestoBlue assays revealed the readily adhesion and proliferation of HCFs over SF adhesives, which confirmed their biocompatibility and potential for use in corneal tissue engineering applications.
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    The comparison of contribution of GO and rGO produced by green synthesis to the properties of CMC-based wound dressing material
    (Elsevier, 2024) Karaca, Özge Gülüzar; Moran, Büşra; Türk, Mustafa; Bal-Öztürk, Ayça; İzbudak, Burçin; Aydın, Yaşar Andelib; Utkan, Güldem; Alemdar, Neslihan
    Herein, GO (graphene oxide) or rGO (reduced graphene oxide) which is produced by the green synthesis method using plant extract (Laurus nobilis) was incorporated into a polymeric structure consisting of carboxymethyl cellulose (CMC) and polyethylene glycol (PEG) to produce a wound dressing material with enhanced mechanical and electrical properties. The effect of GO and rGO on the wound dressing features of the produced materials was investigated and compared to each other. Conductivity tests demonstrated that rGO contributed more significantly to the electrical conductivity than GO. While rGO-CMC/PEG/CA reached 3.01 x 10-6 S.cm- 1 as the conductivity value, that of GO-CMC/PEG/CA was determined as 0.85 x 10-6 S.cm- 1. As for the mechanical tests, it was seen that rGO achieved the best results in terms of elastic modulus (588.62 N/mm2), tensile strength (94.95 MPa) and elongation at break (17.64 %) compared to GO reinforced and pure hydrogel. Curcumin and ascorbic acid were used for antibiotic-free wound treatment and their release kinetics were also modeled. The results showed that rGO reinforced hydrogel provided a more controlled release. All results assured that both the produced GO reinforced and especially rGO reinforced hydrogels could be utilized as modern wound dressing materials with suitable properties to achieve remarkable results for wound healing.