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Öğe The association between red cell distribution width and bone marrow fibrosis in patients with Philadelphia-negative myeloproliferative neoplasms(TR- Dizin, 2022) Aslan, Ceyda; Karışmaz, Abdülkadir; Eren, Refet; Altındal, Şermin; Doğu, Mehmet Hilmi; Suyanı, ElifObjective: Red cell distribution width (RDW) was shown to be increased in primary myelofibrosis (PMF) patients and it is intriguing whether RDW could be used instead of biopsy in predicting presence of bone marrow fibrosis (BMF) to some extend in Philadelphia-negative myeloproliferative neoplasms (MPNs) comprising polycytemia vera (PV), essential thrombocytosis (ET) and PMF. Our aim is to evaluate the relationship between BMF degree and RDW values in patients with MPNs. Method: We retrospectively reviewed the data of 118 patients, who were followed with the diagnosis of MPNs at our Hematology Clinic between 2010 and 2017. Results: 52 patients had PV, 60 had ET, 4 had PMF and 2 had unclassifiable MPN. Twentynine (24.6%) patients were with grade 0 and grade 1 reticulin fibrosis were considered to be free of BMF, and the remaining 89 (75.4%) patients with ? grade 2 reticulin fibrosis were considered to have BMF. The median RDW value was 14.6% (range 12,4-23,1%). The median RDW value revealed with 14.1% (range, 12.4-17.8) in patients without BMF and 15% (range, 12.4-23.1) in patients with BMF (p=0.054). In subgroup analysis of 8 patients with advanced BMF of grade 3, the median RDW value was 18.45% (range, 16.4-23.1) and it was 14.45% (range, 12.4-23) in the remaining 110 patients (p=0.008). Conclusion: Although the present study does not provide a precise conclusion about the association between RDW and BMF, it seems that increased RDW can point out the presence of advanced BMF in patients with MPNs.Öğe Evaluation of the relationship between bone marrow changes and hemogram findings in HIV-positive patients(Galenos publ house, 2025) Karışmaz, Abdulkadir; Cavdar, Vahit Can; Doğu, Mehmet Hilmi; Aslan, Ceyda; Sarı, Nagehan Didem; Erdem Huq, Gülben; Eren, RafetAim: This study aimed to evaluate the relationship between bone marrow (BM) changes and initial laboratory findings in Human immunodeficiency virus (HIV)-positive patients, focusing on hematopoietic system alterations such as myeloid hyperplasia, erythroid hyperplasia, and megakaryocyte activity. Materials and Methods: A total of 57 HIV-positive patients were included in this retrospective study. BM findings, including cellularity, plasma cell ratio, reticulin fiber ratio, and specific features such as myeloid and erythroid hyperplasia, were analyzed. Initial laboratory parameters, including white blood cell (WBC), hemoglobin (HGB), hematocrit (HCT), platelet, and CD4 counts, were assessed. Results: Significant positive correlations were observed between cellularity and WBC (r=0.40, p=0.005), monocyte (r=0.40, p=0.005), and CD8 counts (r=0.32, p=0.02). Plasma cell ratio showed negative correlations with HGB (r=-0.35, p=0.01), HCT (r=-0.35, p=0.01), and albumin (ALB) (r=-0.50, p<0.001). Reticulin fiber ratio was negatively correlated with WBC (r=-0.30, p=0.03), HGB (r=-0.32, p=0.02), and ALB (r=-0.35, p=0.008). Conclusion: BM changes in HIV-positive patients, such as myeloid and erythroid hyperplasia, are associated with significant alterations in peripheral blood parameters, highlighting the importance of comprehensive hematological evaluations in this population. These findings contribute to a better understanding of HIV-related hematopoietic dysfunction and its clinical implicationsÖğe Follicular lymphoma: frequency and timing of treatment: single center experience(Galenos publishing house, 2025) Karışmaz, Abdulkadir; Can Cavdar, Vahit; Serin, İstemi; Doğu, Mehmet Hilmi; Aslan, Ceyda; Eren, RafetIntroduction: This study aimed to investigate how often follicular lymphoma (FL) occurs in patients diagnosed with non-Hodgkin lymphoma (NHL). Additionally, we investigated whether patients with FL required treatment, and if so, whether the need for treatment arose at the initial diagnosis or during subsequent follow-up periods. Methods: Six thousand five hundred sixty patients diagnosed with NHL or chronic lymphocytic leukemia were reached, and healthy data were obtained from 1,719 of them. Data from 176 patients diagnosed with FL were evaluated. Demographic information (age, gender) of the patients was collected. The classifications were grouped by taking into account World Health Organization data, the histological subtype of the tumor, gender and need for treatment were evaluated. Results: Among the patients, 55.1% (n=97) were men and 44.9% (n=79) were women. The median age of those with FL was 50 years, with ages ranging from 18 to 87. When looking at histological subtypes, the FL accounts for 10.2% of cases (n=176). The proportion of patients requiring treatment was 70.9% (125), and the proportion of patients followed up without treatment was 27.8% (49). Of the patients who needed treatment, 57.1% (n=101) required it at the time of diagnosis and 13.6% (n=24) during follow-up. Conclusion: FL, making up around 20% of all NHL, is the second most prevalent type of lymphoma in adults. The incidence, as well as the gender and age distribution, of FL can differ across populations. This may be related to ethnicity, geographical conditions, and socioeconomic status. In addition, the proportion of patients requiring treatment may also vary. When all these are taken into account, social differences are some of the main determinants in the approach to FL.Öğe The connection between anemia and limitations in daily activities among older males: the critical role of dynapenia(Springer science and business media deutschland GmbH, 2024) Karışmaz, Abdulkadir; Soysal, Pınar; Eren, Rafet; Serin, İstemi; Aslan, Ceyda; Rahmati, Masoud; Yon, Dong Keon; Smith, LeeAim The aim of the present study was to examine the relationship between anemia and basic and instrumental activities of daily living in older male patients. Methods A total of 223 older males attending one geriatric outpatient clinic were included in this cross-sectional study. Anemia was defined as a hemoglobin level below 13 g/dL. Patients' demographic characteristics, comorbidities, and comprehensive geriatric assessment parameters were also recorded. Handgrip strength of < 27 kg for males was accepted as dynapenia. Basic Activities of Daily Living (BADL) and Instrumental Activities of Daily Living (IADL) questionnaires were used to evaluate functional capacity. Results The mean age (standard deviation) of the participants was 80.17 (7.69) years. The prevalence of patients with anemia was 43.9%. There was differences between anemic and non-anemic groups in terms of presence of diabetes mellitus (DM), congestive heart failure (CHF), chronic kidney disease (CKD), malnutrition, dynapenia, geriatric depression, BADL and IADL scores (all p < 0.05). In multivariate analysis, after adjusting for all confounding variables except for dynapenia, patients with anemia were associated with reduced BADL and IADL (all p < 0.05). After adjusting for all confounding variables including dynapenia, deterioration in total BADL and IADL scores did not remain significant in the anemic group compared to the non-anemic group (p > 0.05). Conclusion Close to one in two older outpatient men had anemia. Anemic men had a higher incidence of DM, CHF, CKD, malnutrition, geriatric depression and dynapenia. Anemia was associated with dependence in both BADL and IADL in older men. However, comorbidities, nutritional status, depressive mood and, specifically muscle strength, were important contributors to this association.
